Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2007, Vol. 18 ›› Issue (5): 294 doi: 10.1016/S1001-8042(07)60064-5

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Influencing factors of radioiodine therapy in hyperthyroidism in adults

XU Jiehua1 ZHANG Zikang1 CHENG Muhua1 WANG Ping2 WU Chunxing1 SHAN Hong3*   

  1. Department of Nuclear Medicine, No.3 Hospital Affiliated to Sun Yat-sen University, Guangzhou 510630, China;
    2 Department of Infection Disease, No.3 Hospital Affiliated to Sun Yat-sen University, Guangzhou 510630, China;
    3 Department of Radiology, No.3 Hospital Affiliated to Sun Yat-sen University, Guangzhou 510630, China
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XU Jiehua ZHANG Zikang CHENG Muhua WANG Ping WU Chunxing SHAN Hong. Influencing factors of radioiodine therapy in hyperthyroidism in adults.Nuclear Science and Techniques, 2007, 18(5): 294     doi: 10.1016/S1001-8042(07)60064-5
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Abstract: The study was to evaluate factors affecting outcome of 131I therapy in hyperthyroidism for optimizing the method. Data from 213 patients who received 131I treatment from July 2003 to July 2005 in our department were ret-rospectively analyzed. Factors possibly contributing to the outcome of the 131I therapy were analyzed, including gen-der, age, history of antithyroid drug, thyroid volume, duration of disease and radioactive iodine uptake rate. Multivari-ate analysis was done. The rates of euthyroidism and hypothyroidism were 69% and 8.5%, respectively, after one time 131I therapy. Multivariate analysis of the patients showed no statistically significant factors affecting the outcome of 131I therapy. The study showed that 131I dose can be directly calculated, and this simplifies the dose-determined method and individualizes the therapy.

Key words: Iodine-131, Hyperthyroidism, Factors, Adult