Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2007, Vol. 18 ›› Issue (4): 232 doi: 10.1016/S1001-8042(07)60052-9

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Comparable investigation in dopamine transporters with 99mTc-TRODAT-1 and 131I-FP-CIT SPECT in Parkinson’s disease patients

LIU Congjin1 LIU Xingdang1* ZHANG Guangming1 LI Ding1 WANG Jian2 YANG Liqin2 JIANG Yuping2   

  1. 1 Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;
    2 Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
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LIU Congjin LIU Xingdang ZHANG Guangming LI Ding WANG Jian YANG Liqin JIANG Yuping. Comparable investigation in dopamine transporters with 99mTc-TRODAT-1 and 131I-FP-CIT SPECT in Parkinson’s disease patients.Nuclear Science and Techniques, 2007, 18(4): 232     doi: 10.1016/S1001-8042(07)60052-9
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Abstract: Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1 and FP-CIT were observed in evaluating DAT change of Parkinson’s disease (PD). The relationship between them was also evaluated. The results suggested that 99mTc-TRODAT-1 SPECT and 131I-FP-CIT SPECT may serve as sensitive and objective in vivo markers to reflect the severity of PD. The 99mTc-TRODAT-1 image is more accurate and clearer compared with 131I-FP-CIT.

Key words: 99mTc-TRODAT-1 SPECT, 131I-FP-CIT SPECT, Parkinson’s disease