Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2006, Vol. 17 ›› Issue (1): 48 doi: 10.1016/S1001-8042(06)60011-0

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Synthesis and application of PLGA labeled with 125I

HUA Nan SUN Jiao*   

  1. The Ninth People's Hospital, Shanghai Jiaotong University/Shanghai Biomaterial Research and Test Center, Shanghai 200011, China
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HUA Nan SUN Jiao. Synthesis and application of PLGA labeled with 125I.Nuclear Science and Techniques, 2006, 17(1): 48     doi: 10.1016/S1001-8042(06)60011-0

Abstract: The weight loss in vivo degradation of poly (lactide-co-glycolide) (PLGA) radiolabeled with 125I was investigated. PLGA with molecular weight (Mw) of 84000(LA/GA = 85/15) were labeled with 125I in the chloroform media by circularly heating and round films of about 15 mm in diameter were formed. The composition and Mw of the 125I-PLGA were characterized by 1 H-NMR and viscosimeter. The weight loss of this copolymer in vitro and in vivo degradation was quantified by determining radioactivity of materials. The results indicated that PLGA exhibited significantly faster degradation in vivo than that of in vitro conditions.

Key words: Poly (lactide-co-glycolide), 125I labeling, Degradation.