Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2019, Vol. 30 ›› Issue (5): 71 doi: 10.1007/s41365-019-0599-x


Quantum dots enhanced Cerenkov luminescence imaging

Chang-Ran Geng1,2 • Yao Ai1,2 • Xiao-Bin Tang1,2 • Di-Yun Shu1,2 • Chun-Hui Gong1,2 • Ming-Hua Du3 • Fa-Quan Ji3   

  1. 1 Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
    2 Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Nanjing 210016, China
    3 Affiliated Hospital of Nanjing University of TCM, Nanjing 210016, China
  • Received:2018-09-04 Revised:2018-12-22 Accepted:2019-01-03
  • Contact: Xiao-Bin Tang
  • Supported by:
    This work was supported in part by the Natural Science Foundation of Jiangsu Province (No. BK20180415), the National Natural Science Foundation of China (No. 11805100), the Fundamental Research Funds for the Central Universities (No. NS2018041), and the National Key Research and Development Program (Nos. 2016YFE0103600 and 2017YFC0107700).
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Chang-Ran Geng, Yao Ai, Xiao-Bin Tang, Di-Yun Shu, Chun-Hui Gong, Ming-Hua Du, Fa-Quan Ji. Quantum dots enhanced Cerenkov luminescence imaging.Nuclear Science and Techniques, 2019, 30(5): 71     doi: 10.1007/s41365-019-0599-x

Abstract: Cerenkov luminescence imaging (CLI) has been widely investigated for biological imaging. However, the luminescence generated from Cerenkov effect is relatively weak and has poor penetration ability in biological tissues. These limitations consequently hindered the clinical translation of CLI. In this study, we proposed an in vitro experimental study for the demonstration of quantum dots (QDs) configurations affected by the improvement of the signal intensity of CLI. Results revealed that the optimal concentrations were 0.1 mg/mL and 0.25 mg/mL for the studied CdSe/ZnS QDs with fluorescence emission peaks of 580 nm and 660 nm, respectively. The detected optical signal intensity with long-wavelength emission QDs were stronger than those with short-wavelength emission QDs. This study illustrates an experiment to study the effects of concentrations and fluorescence emission peaks of QDs on an enhanced optical signal for the external detection of CLI.

Key words: Cerenkov luminescence imaging, Quantum dots, Optical signal, Wavelength shift