Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2018, Vol. 29 ›› Issue (9): 131 doi: 10.1007/s41365-018-0470-5


Mechanical-force–promoted peptide assembly: a general method

Yue Yuan 1,2 • Qi-Qi-Ge Du 2,3 • Yu-Jiao Wang 2 • Jun Hu 2 • Shi-Tao Lou 1 • Yi Zhang 2   

  1. 1 State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200062, China
    2 Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    3 School of Life Sciences, Inner Mongolia Agricultural University, Hohhot 010018, China
  • Contact: Yi Zhang
  • Supported by:

    This work was supported by the National Natural Science Foundation of China (No. 11674344), the National Basic Research Program of China (973 program, No. 2013CB932801), and the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (No. QYZDJ-SSW-SLH019-2).

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Yue Yuan, Qi-Qi-Ge Du, Yu-Jiao Wang, Jun Hu, Shi-Tao Lou, Yi Zhang. Mechanical-force–promoted peptide assembly: a general method.Nuclear Science and Techniques, 2018, 29(9): 131     doi: 10.1007/s41365-018-0470-5


A general method was developed for promoting peptide assembly and protein polymerization to form nanoscale patterns on various surfaces with an atomic force microscope (AFM) operated in a liquid. By scanning solid surfaces with an AFM tip, we showed that peptide monomers assemble at a higher rate in the tip-scanned area compared to other regions. The promotion is attributed to the mechanical force applied by the scanning tip. This kind of mechanical-force-promoted assembly was also observed with different peptides on various substrates. The force promoting peptide assembly provides a simple and practical solution for preparing and building peptide and protein architectures for future nanodevices.

Key words: Self-assembly, Peptide, Nanomechanical stimulus, Support lipid bilayers, Atomic force microscope