Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2017, Vol. 28 ›› Issue (10): 138 doi: 10.1007/s41365-017-0294-8

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE •     Next Articles

Improving detecting efficiency of suspected gastrointestinal tumors with dual-time-point 18F-FDG PET/CT

Jian-Hua Song 1  Jin-Hua Zhao 1  Xue-Qian Xie 2 Yan Xing 1  Xiang Chen Wen-Li Qiao 1 Chang-Cun Liu 1  Tai-Song Wang 1   

  1. 1 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd., Shanghai 200080, China
    2 Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd., Shanghai 200080, China
  • Contact: Jin-Hua Zhao E-mail:zhaojinhua1963@126.com
PDF ShareIt Export Citation
Jian-Hua Song, Jin-Hua Zhao, Xue-Qian Xie, Yan Xing, Xiang Chen, Wen-Li Qiao, Chang-Cun Liu, Tai-Song Wang. Improving detecting efficiency of suspected gastrointestinal tumors with dual-time-point 18F-FDG PET/CT.Nuclear Science and Techniques, 2017, 28(10): 138     doi: 10.1007/s41365-017-0294-8
Citations
Altmetrics

Abstract:

We conducted a retrospective analysis of 221 subjects with 256 suspected gastrointestinal lesions from 2007 to 2015 to explore the detecting efficiency of dual-time-point fluorine-18 fludeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and pathology examination. The abdominal delayed PET/CT was performed within 45 min of the conventional scan. The change in maximum standardized uptake value (ΔSUVmax) and morphological features of the suspected lesions between the conventional and dual-time-point PET/CT were compared. The sensitivity, specificity, positive predictive value, and negative predictive value (NPV) of conventional PET/CT were 81.6% (84/103), 56.2% (86/153), 55.6% (84/151), and 81.9% (86/105), respectively. Those of dual-time-point PET/CT were 94.1% (97/103), 78.4% (120/153), 74.6% (97/130), and 95.2% (120/126), respectively. There was a significant difference between the conventional and dual-time-point PET/CT (P < 0.005). The SUVearly and the %ΔSUVmax could not present more information in differential diagnoses, but the rate of tumors with increased SUVdelay accounted for 79.6% (82/103) and more than that of nonneoplastic lesions (15.5%, 29/187) (x2 = 115.5, P < 0.01). Therefore, the dual-time-point 18F-FDG PET/CT had a higher sensitivity and NPV than the conventional PET/CT to detect gastrointestinal tumors. The constant morphology and increased SUVdelay help to detect the tumors and adding delayed imaging on the locality will be an effective method when we accidentally find a suspected gastrointestinal tumor on the conventional PET/CT images.

Key words: 18F-FDG, PET/CT, Gastrointestinal tumors, Dual-time-point imaging