Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2017, Vol. 28 ›› Issue (3): 35 doi: 10.1007/s41365-017-0191-1

• NUCLEAR PHYSICS AND INTERDISCIPLINARY RESEARCH • Previous Articles     Next Articles

Construction of DNA-based logic gates on nanostructured microelectrodes

Tao Wei 1,2  Min Li 2  Yue-Yue Zhang 2  Ali Aldalbahi 3  Li-Hua Wang 2  Xiao-Lei Zuo Yun Zhao 1   

  1. 1 Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China
    2 Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    3 Chemistry Department, King Saud University, Riyadh 11451, Saudi Arabia
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Tao Wei, Min Li, Yue-Yue Zhang, Ali Aldalbahi, Li-Hua Wang, Xiao-Lei Zuo, Yun Zhao. Construction of DNA-based logic gates on nanostructured microelectrodes.Nuclear Science and Techniques, 2017, 28(3): 35     doi: 10.1007/s41365-017-0191-1
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Abstract:

Electrochemical logical operations utilizing biological molecules (protein or DNA), which can be used in disease diagnostics and bio-computing, have attracted great research interest. However, the existing logic operations, being realized on macroscopic electrode, are not suitable for implantable logic devices. Here, we demonstrate
DNA-based logic gates with electrochemical signal as output combined with gold flower microelectrodes. The designed logic gates are of fast response, enzyme-free, and
micrometer scale. They perform well in either pure solution or complex matrices, such as fetal bovine serum, suggesting great potential for in vivo applications.

Key words: Logic gates, Microelectrode, Bio-computing, Electrochemical, Nanostructured electrode