Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2016, Vol. 27 ›› Issue (2): 29 doi: 10.1007/s41365-016-0030-9

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Diagnostic value of [18F]FDG-PET/CT in acute hepatic radiation toxicity: a Tibet minipig model

Lei Fu 1, Chi Chen 2, Yu-Guang Tian 3, Kun-Yuan Guo 4, Shao-Jie Wu 4, Yu-Jue Wang 3   

  1. 1 School of Nursing, The Hospital Affliated to Guizhou Medical University, Guiyang 550001, China
    2 Section of Immune and Microbes, Guiyang College of Traditional Chinese Medicine, Guiyang 550001, China
    3 Laboratory Animal Center, Southern Medical University, Guangzhou 510282, China
    4 Department of Hematology, Zhujiang Hospital, Guangzhou 510282, China
  • Contact: Yu-Jue Wang E-mail:783805387@qq.com
  • Supported by:

    Supported by the Third Phase Project of Chinese National 211 Leading Academic Discipline (No. C1030380), Natural Science Foundation of China (No. 81402625 ) and Natural Science Foundation of Guangdong Province (No. S2013010014720).

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Lei Fu, Chi Chen, Yu-Guang Tian, Kun-Yuan Guo, Shao-Jie Wu, Yu-Jue Wang. Diagnostic value of [18F]FDG-PET/CT in acute hepatic radiation toxicity: a Tibet minipig model.Nuclear Science and Techniques, 2016, 27(2): 29     doi: 10.1007/s41365-016-0030-9

Abstract:

There are few reports with respect to the details of acute effects (during and following RT) of ionizing radiation in liver tissue in epidemiology, pathology, physiology and imageology. Therefore, this study was undertaken to assess the diagnostic value of 2-[18F18F]-fluoro-2-deoxy-D-glucose positron emission tomography with computed tomography ([18F18F]-FDG-PET/CT) in the detection of acute radiation toxicity in normal liver using Tibet minipigs as a model. Thirty-six male Tibetan minipigs were randomly divided into six groups (n=6n=6). The irradiation groups were treated with a single dose of 2,5,8,11 and 14 Gy2,5,8,11 and 14 Gy total body irradiation using an 8-MV X-ray linac, at dose rate of 255 cGy/min255 cGy/min. The control group was not irradiated. The pigs were evaluated with [18F18F]-FDG-PET/CT, and their alanine aminotransferase (AST) and aspartate aminotransferase (ALT) activities and the ALT/AST ratio, INRatio and bilirubin were measured on Day 7 post-TBI. All pigs were killed on Day 7 post-TBI to collect liver tissues for pathological examination. The results showed that liver standardized uptake value (SUV) increased with the dose from 2 to 11 Gy and decreased suddenly at 14 Gy14 Gy. HAI score showed a radiation dose-dependent increase of 2–11 Gy and was positively correlated with SUV (p<0.05p<0.05). However, HAI score showed no correlation with liver function. Therefore, we concluded that [18F18F]-FDG-PET/CT has the potential to assess acute radiation-induced hepatic injury on early stage.

Key words: [18F]FDG-PET/CT, Acute response, Total body irradiation, Liver