Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2016, Vol. 27 ›› Issue (1): 13 doi: 10.1007/s41365-016-0002-0

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Measurement of trace element content in bone samples using long-lived neutron activation products and high-resolution gamma-ray spectrometry

Vladimir Zaichick 1, Sofia Zaichick 2   

  1. 1. Radionuclide Diagnostics Department, Medical Radiological Research Centre, Korolyev St. 4, Obninsk, Russia, 249036
    2. Department of Medicine, University of Illinois, College of Medicine at Chicago, COMRB 1160-1168, Chicago, IL, 60612, USA
  • Contact: Vladimir Zaichick E-mail:vezai@obninsk.com
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Vladimir Zaichick, Sofia Zaichick. Measurement of trace element content in bone samples using long-lived neutron activation products and high-resolution gamma-ray spectrometry.Nuclear Science and Techniques, 2016, 27(1): 13     doi: 10.1007/s41365-016-0002-0
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Abstract:

A nondestructive instrumental neutron activation analysis with high-resolution gamma-ray spectrometry of long-lived radionuclides was developed and used for measurement of trace element contents in samples of bone to determine health and diseases. Using this method, the silver (Ag), cobalt (Co), chromium (Cr), iron (Fe), mercury (Hg), rubidium (Rb), antimony (Sb), selenium (Se), and zinc (Zn) mass fractions were estimated in bone samples from 27 patients with intact bone (12 females and 15 males, aged from 16 to 49 years) who had died from various non-bone-related causes, mainly unexpected traumas, and from 5 patients with chondroma (2 females and 3 males, 15–42 years old), obtained from open biopsies or after operation. The reliability of the differences in the results between intact bone and bone affected by chondroma was evaluated by a parametric Student’s t test and a nonparametric Mann–Whitney U test. It was found that in the bone affected by chondroma, the mean mass fractions of Co, Cr, Fe, Se, Sb, and Zn were significantly higher than in normal bone tissues. In the neoplastic bone, many correlations between trace elements found in the control group were no longer evident. This work revealed that there is a significant disturbance of the trace element metabolism in bone affected by chondroma.

Key words: Neutron activation analysis, Trace elements, Human bone, Bone tumors