硅油对淀粉样蛋白和多肽积聚的促进作用

doi:10.11889/j.0253-3219.2015.hjs.38.080501

Nuclear Techniques ›› 2015, Vol. 38 ›› Issue (8): 80501-080501.doi: 10.11889/j.0253-3219.2015.hjs.38.080501

• NUCLEAR PHYSICS, INTERDISCIPLINARY RESEARCH • Previous Articles Next Articles

Silicone oil promotes the aggregation of amyloid proteins and peptides

LI Jia1 LEI Haozhi1 DAI Bin2 QI Qige1 ZHANG Yi1 HU Jun1

1(Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Jiading Campus, Shanghai 201800, China) 2(The Interdisciplinary Research Center of Biology and Chemistry, Chinese Academy of Sciences, Shanghai 200032, China)

Received:2015-03-18 Revised:2015-04-10 Online:2015-08-10 Published:2015-08-13

Abstract

Abstract: Background: The aggregation of amyloid proteins leads to some serious diseases, such as Alzheimer’s disease, Parkinson’s disease; silicone oil is identified as biosafety material, and is widely used in industry and daily life, even implantation in vivo. Purpose: The aim is to study the influence of silicone oil on the aggregation of amyloid proteins and peptides. Methods: We measured the fluorescence of thioflavin T(ThT) in the samples and image the aggregated fibers by atomic force microscope (AFM). Results: Five kinds of amyloid proteins/peptides aggregated faster and more sufficiently in the samples containing silicone oil, and the fibers are longer and denser in silicone oil sample. Conclusion: A certain amount of silicone oil can promote the aggregation of these amyloid proteins and peptides.

Key words: Silicone oil, Amyloid protein, Vibration, Aggregation

LI Jia, LEI Haozhi, DAI Bin, QI Qige, ZHANG Yi, HU Jun. Silicone oil promotes the aggregation of amyloid proteins and peptides[J].Nuclear Techniques, 2015, 38(8): 80501-080501.

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Silicone oil promotes the aggregation of amyloid proteins and peptides

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