呼吸道含铀化合物滞留廓清模型及单次吸入肺部滞留量计算

doi:10.11889/j.0253-3219.2019.hjs.42.110302

Nuclear Techniques ›› 2019, Vol. 42 ›› Issue (11): 110302-110302.doi: 10.11889/j.0253-3219.2019.hjs.42.110302

• NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles Next Articles

Human respiratory tract model of uranium-containing compounds and calculation of pulmonary retention under single inhalation

Weiye YUAN,Yidi WANG,Yue XI,Liang SUN,Yu TU()

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection and Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China

Received:2019-07-02 Revised:2019-09-17 Online:2019-11-10 Published:2019-11-18
Contact: Yu TU E-mail:tuyu@suda.edu.cn
Supported by:
National Natural Science Foundation of China(11575124);Nuclear Energy Development Project([2016]1295)

Abstract

Abstract: Background

In the production process of nuclear industry, excessive intake of aerosols uranium-containing compounds due to accidents or other circumstances occurs from time to time.

Purpose

This study aims to investigate the deposition and transfer of internal contamination caused by inhalation of radioactive uranium aerosols.

Methods

The latest respiratory tract model based on the Simulink simulation tool in MATLAB software was established according to the 130th report published by the ICRP (International Commission on Radiological Protection). Distribution and retention of uranium aerosols in the lung were simulated by combining with the specific biological metabolism and physical characteristics of several uranium containing compounds, so as to evaluate and predict the health hazard of internal pollution to patients.

Results

Simulation results show that 55.37% of single inhalation of UF₆ entered the gastrointestinal tract and 12.89% was absorbed by blood and discharged from the lungs within the next few days. After inhalation of ADU, UO₃ and UF₄, these compounds stay in the lungs for a long time, and it takes about 300~1 000 days to clear from the lungs. Insoluble compounds such as UO₂ and U₃O₈ will remain in the lung for more than 20 years.

Conclusions

The distribution and retention of different uranium compounds in vivo are different, and the treatment method needs to be selected according to the actual situation.

Key words: Internal irradiation, MATLAB, Uranium, Biokinetics

CLC Number:

R144

Weiye YUAN, Yidi WANG, Yue XI, Liang SUN, Yu TU. Human respiratory tract model of uranium-containing compounds and calculation of pulmonary retention under single inhalation[J].Nuclear Techniques, 2019, 42(11): 110302-110302.

Figures/Tables 11

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	F	M	S	ADU/UO₃	U₃O₈/UO₂	UF₆	UF₄
λ _p→t	0	2.396	2.970	0.198	0.969 5	0	2.396
λ _p→b	0	0	0	0	0	0	0
λ _P→blood	30	0.604	0.030 1	0.802	0.034 985	10	0.604
λ _t→b	0	0	0	0	0	0	0
λ _t→blood	0	0.005	0.000 1	0.01	0.000 5	0	0.005
λ _b→blood	0	0	0	0	0	0	0

摄入后时间Day after intake / d	自编肺模型计算值The results of Simulink model	文献[13]值Results of Ref.[13]	与文献值的相对偏差Relative deviation from literature / %
1	0.061 7	0.061 9	-0.32
3	0.058 6	0.058 7	-0.17
7	0.055 0	0.055 1	-0.18
15	0.052 1	0.052 1	0.0
30	0.050 1	0.050 1	0.0
60	0.047 1	0.047 1	0.0
100	0.043 6	0.043 6	0.0
300	0.031 1	0.031 1	0.0
1 000	0.017 2	0.017 2	0.0
10 000	0.004 83	0.004 83	0.0

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Human respiratory tract model of uranium-containing compounds and calculation of pulmonary retention under single inhalation

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