Nuclear Techniques ›› 2020, Vol. 43 ›› Issue (7): 70103-070103.doi: 10.11889/j.0253-3219.2020.hjs.43.070103

• SYNCHROTRON RADIATION TECHNOLOGY AND APPLICATIONS • Previous Articles     Next Articles

Characterization of dermal fiber architecture based on X-ray phase contrast micro-tomography

Mingxia YUAN1,Xiaowei CHEN1,Bo SONG1,Xiangzhi ZHANG3,Hongyi LI2()   

  1. 1.Terahertz Technology Innovation Research Institute, School of Optical Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
    2.Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
    3.Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China
  • Received:2020-01-27 Revised:2020-03-20 Online:2020-07-15 Published:2020-07-16
  • Contact: Hongyi LI E-mail:leehongyi@bjhmoh.cn
  • About author:YUAN Mingxia, female, born in 1994, graduated from Jingchu University of Technology in 2016, master student, focusing on optics research
  • Supported by:
    Clinical Research 121 Program of Beijing Hospital(121-2016002);National Natural Science Foundation of China(U1832154);Shanghai Youth Science and Technology Talent Development Program(19YF143410);Youth Innovation Promotion Association of Chinese Academy of Sciences(2019291)

Abstract: Background

More and more studies have shown that the tissue fluid in the skin can flow along the fiber track for a long distance. This fluid flow with fiber filaments as the orbit is related to the fiber skeleton of the dermis and subcutaneous tissue layers, and the three-dimensional fiber skeleton structure has not been characterized.

Purpose

This study aims provide a high-resolution characterization method for understanding the long-range flow phenomenon of tissue fluid in the skin.

Methods

X-ray phase contrast microscopy imaging technology in the Shanghai Synchrotron Radiation Facility (SSRF) BL13W1 beamline was employed to obtain the three-dimensional fiber skeleton structure inside the dermis and subcutaneous tissue layer. Combined with computer graphics, we successfully characterized the three-dimensional fiber skeleton in human skin.

Results

It is found that the fibrous skeleton in the dermis has a long-range order and is closely related to the depth of the dermis.

Conclusions

This study provides a high resolution characterization method for understanding the long-range flow of tissue fluid in skin.

Key words: Image Processing, Fiber skeleton, X-ray phase contrast microtomography, Synchrotron radiation technology

CLC Number: 

  • TL99