Nuclear Techniques ›› 2016, Vol. 39 ›› Issue (8): 80301-080301.doi: 10.11889/j.0253-3219.2016.hjs.39.080301

• NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Fully automated synthesis of 18F-FDG by acidic hydrolysis on domestic module

LI Haifeng1, ZHANG Xiaojun2, LI Yungang2, ZHANG Jinming2   

  1. 1 Department of Nuclear Medicine, Jiang Xi Cancer Hospital, Nanchang 330029, China;
    2 Department of Nuclear Medicine, The People's Liberation Army(PLA) General Hospital, Beijing 100853, China
  • Received:2016-04-03 Revised:2016-04-29 Online:2016-08-10 Published:2016-08-15
  • Supported by:

    Supported by the Enhancing Program of Military Hospital Prepared Medicine (No.14ZJZ2101)

Abstract:

Background: The FDG 18F-fluorodeoxyglucose (18F-FDG) synthesis module was obtained by one process of production generally. The adjusting of synthetic technology would have a significant influence on the quality of product. Purpose: In order to solve the problem and optimize the production process, in this paper, the domestic FDG synthesis module has been improved. Methods: The domestic FDG synthesis module of basic hydrolysis was optimized by removing the components of automatic alkali-adding and on-column hydrolysis. The influencing factors of synthesis process were discussed, including the time of nucleophilic reaction, the amount of HCl, the hydrolysis time and the residual solvents. Results: It took 27 min from 18F- to final product of 18F-FDG, and a radiochemical yield of 60.27%±2.29% (n=37, End of Synthesis (EOS)) was obtained. The radiochemical purity of 18F-FDG was higher than 98% and the radioactivity was (29.15±3.09) GBq (n=37). Conclusion: The synthetic process was reliable and automated, and the product was suitable for clinical use. Finally, two different processes were used for synthesizing 18F-FDG on the same module.

Key words: 18F-FDG, Automated synthesis, PET/CT (Positron emission tomography/computer tomography), Quality control

CLC Number: 

  • TL92+3