Nuclear Techniques ›› 2014, Vol. 37 ›› Issue (07): 70202-070202.

• LOW ENERGY ACCELERATOR, RAY AND APPLICATIONS •

### Feasibility and improvement of biological imaging technique based on Cerenkov effect

HOU Xiaoxiao TANG Xiaobin GENG Changran SHU Diyun CHEN Da

1. (Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China)
• Received:2014-02-20 Revised:2014-04-14 Online:2014-07-10 Published:2014-07-07

Abstract: Background: There are several defects in traditional optical imaging such as background interference, toxic fluorescence stain, low stability etc. Similar problems can be avoided by use of Cerenkov light for optical imaging. Purpose: This work is to confirm the feasibility of Cerenkov light imaging in theory, find the shortage of Cerenkov light imaging, seek the feasible solution. Methods: Using the Monte Carlo method, (1) Simulate the condition that decay particles from three kinds of radioactive source (18F, 131I, 32P) produce Cerenkov light, analyze the relationship between thickness of the muscle and the number of Cerenkov photons; (2) Exchange the radioactive source to light source, analyze the penetration of photon in different wavelengths within Cerenkov light wavelength range. Results: The feasibility of Cerenkov light imaging is verified by using Monte Carlo method, penetrability of single Cerenkov light is poor, however, penetrability appears better of Cerenkov light in long wavelength. Conclusion: Cerenkov light imaging can be used as a novel imaging method, it has promising application. The problem of poor penetrability can be solved by giving a way to make the wavelength of Cerenkov light "red-shift".