电离辐射对职业人群抗氧化酶活性和丙二醛含量影响的Meta分析

doi:10.11889/j.1000-3436.2019.rrj.37.030701

Journal of Radiation Research and Radiation Processing ›› 2019, Vol. 37 ›› Issue (3): 7-030701-11.doi: 10.11889/j.1000-3436.2019.rrj.37.030701

• RADIATION INTERDISCIPLINARY RESEARCH • Previous Articles Next Articles

Meta-analysis of effects of ionizing radiation on antioxidant enzyme and malondialdehyde levels of occupational population

LIU Liangli(),CHEN Xianglan,FENG Shuidong()

School of Public Health, University of South China, Hengyang 421001, China

Received:2019-01-08 Revised:2019-03-21 Accepted:2019-03-21 Online:2019-06-20 Published:2019-06-18
Contact: Shuidong FENG E-mail:879004657@qq.com;shuidong_f@hotmail.com
About author:LIU Liangli (female) was born in March 1993, and graduated from Chuanshan College, University of South China in 2016. Now she is a master candidate at University of South China, majoring in public health. E-mail: 879004657@qq.com
Supported by:
Supported by Natrual Science Foundation of Hunan Province(2018JJ2342)

Abstract

Abstract:

In order to review the influence of ionizing radiation on antioxidant enzyme activity and malondialdehyde (MDA) levels, relevant literatures databases, such as the China National Knowledge Infrastructure (CNKI), VIP database, Wanfang database, The Cochrane Library, Web of Science, Pubmed, and EMbase, were searched until September 2018. Two reviewers independently screened these papers and evaluated the risk of bias. The extracted data were analyzed using Stata 12.0 software. A total of 14 literatures involving 1 733 radiation workers and 1 796 controls were included. The results of meta-analysis showed that the level of malondialdehyde and the activity of superoxide dismutase increased in the exposed than in the unexposed group (SMD=1.284, 95% CI: 0.74~1.828, p=0; SMD=0.681, 95% CI: 0.056~1.306, p=0.033), while there was no statistical significance observed in the activity of glutathione peroxidase and catalase, respectively (SMD=?0.106, 95% CI: ?0.458~0.246, p=0.554; SMD=1.175, 95% CI: ?0.331~2.681, p=0.126). The subgroup analysis stratified by work showed that compared with the unexposed group, the level of malondialdehyde was increased in themedical, industrial detecting and other groups, while the activity of superoxide dismutase was increased in medical group but decreased in industrial detecting group. The subgroup analysis stratified by work year showed that, compared with the unexposed group, the level of malondialdehyde and the activity of superoxide dismutase were increased in groups whose work age was higher than 12.56 a. While the subgroup analysis stratified by annual effective dose showed that, compared with the unexposed group, the level of malondialdehyde was increased in all groups and the activity of superoxide dismutase was decreased in groups whose dose was higher than 1.19 mSv/a. The results indicate that ionizing radiation can cause damage of lipid peroxidation with increased malondialdehyde; however its influence on antioxidant enzymes still needs further research.

Key words: Ionizing radiation, Antioxidant enzyme, Malondialdehyde, Occupational exposure

CLC Number:

R148，TL7

LIU Liangli, CHEN Xianglan, FENG Shuidong. Meta-analysis of effects of ionizing radiation on antioxidant enzyme and malondialdehyde levels of occupational population[J].Journal of Radiation Research and Radiation Processing, 2019, 37(3): 7-030701-11.

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References 26

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参考文献 Refe- rences	作者 Author	年限 Year	例数（暴露组/ 对照组） Cases (exposed group/controls)	工种类型 Types of work	工龄 / a Working years	年有效剂量 / mSv?a^?1 Annual effec- tive dose	研究指标 Study indexes
[6]	董小梅 DONG Xiaomei	2015	31/49	工业探伤 Industrial detection	?	0.15 (0.12~0.21)	①②③④
[6]	董小梅 DONG Xiaomei	2015	253/118	医疗放射^a Medical radiology^a	10.18	0.52 (0.12~4.76)	①②③④
[7]	彭珊茁 PENG Shanzhuo	2003	121/244	医用射线 Medical rays	15 (1~30)	0.15~0.6	①③
[7]	彭珊茁 PENG Shanzhuo	2003	97/244	工业探伤 Industrial detection	15 (1~30)	0.15~0.6	①③
[8]	宣志强 XUAN Zhiqiang	2013	61/65	医用射线 Medical rays	?	0.36 (0.06~1.68)	①②③
[9]	刘剑英 LIU Jianying	2009	80/30	其他^b Other type^b	?	?	①②③
[10]	张元军 ZHANG Yuanjun	2005	285/270	其他 Other type	11.3 (1~34)	2.19 (0.32~8.17)	①③
[11]	聂木海 NIE Muhai	2005	322/298	其他 Other type	18.6	?	①②③
[12]	张冰洁 ZHANG Bingjie	1999	57/46	医用射线 Medical rays	?	2.1 (1.54~5)	①②③
[13]	K?uciński P	2008	45/30	医用射线 Medical rays	?	0~1	②③④
[14]	Kumar D	2016	85/51	医用射线 Medical rays	6.51	?	①③
[15]	Serhatlioglu S	2003	57/21	其他 Other type	?	?	①
[16]	Hajer D	2017	29/154	放射诊断 Diagnostic radiology	14.65 (3~33)	?	①②③④
[17]	Kumar D	2014	83/51	医用射线 Medical rays	6.51	?	①③
[18]	Eken A	2012	40/30	医用射线 Medical rays	8	0.32	①②③④
[19]	Kayan M	2009	20/30	医用射线 Medical rays	?	0.27	②

参考文献 References	对象选择 Selection	可比性 Comparability	暴露测量 Exposure	评分 Score	质量 Quality
[6]	★★★	★	★★	6	高High
[7]	★★	★	★★	5	低Low
[8]	★★★	★★	★★	7	高High
[9]	★★	★★	★	5	低Low
[10]	★★★	★★	★★	7	高High
[11]	★★	★	★	4	低Low
[12]	★★★	★★	★★★	8	高High
[13]	★★	★	★★	5	低Low
[14]	★★★	★	★	5	低Low
[15]	★★	★	★★	5	低Low
[16]	★★	★	★★	5	低Low
[17]	★★★★	★	★★	7	高High
[18]	★★★★	★★	★★	8	高High
[19]	★★	★	★★	5	低Low

指标 Index	工种类型 Work type	研究数量 Number	效应估计值Effect estimate		异质性检验Heterogeneity test
指标 Index	工种类型 Work type	研究数量 Number	SMD (95%CI)	p value	p value	I ²
丙二醛含量 Level of MDA	医疗^a Medical group^a	9	1.749 (0.749, 2.748)	0.001	0	98.6
	工业探伤 Industrial detection	2	1.388 (0.209, 2.567)	0.021	0	93.5
	其他^b Other type^b	4	0.882 (0.273, 1.491)	0.005	0	95.5
超氧化物歧化酶活性 Activity of SOD	医疗^a Medical group^a	10	1.643 (0.762, 2.524)	0	0	98.3
	工业探伤 Industrial detection	2	?0.444 (?0.705, ?0.183)	0.001	0.258	21.7
	其他^b Other type^b	3	?0.925 (?2.092, 0.242)	0.120	0	98.7

指标 Index	工龄 / a Work year	研究数量 Number	效应估计值Effect estimate		异质性检验Heterogeneity test
指标 Index	工龄 / a Work year	研究数量 Number	SMD (95% CI)	p value	p value	I ²
丙二醛含量 Level of MDA	<12.56	5	?0.164（?1.235, 0.907）	0.764	0	98.5
丙二醛含量 Level of MDA	≥12.56	4	3.745（2.367, 5.123）	0	0	99.1
超氧化物歧化酶活性 Activity of SOD	<12.56	5	0.509（?0.870, 1.887）	0.469	0	99.1
超氧化物歧化酶活性 Activity of SOD	≥12.56	4	4.011（2.464, 5.558）	0	0	99.3

指标 Index	年有效剂量 Dose / mSv?a^?1	研究数量 Number	效应估计值 Effect estimate		异质性检验 Heterogeneity test
指标 Index	年有效剂量 Dose / mSv?a^?1	研究数量 Number	SMD (95% CI)	p value	p value	I ²
丙二醛含量 Levels of MDA	<1.19	6	0.649(0.077, 1.221)	0.026	0	95.1
丙二醛含量 Levels of MDA	≥1.19	3	1.401(1.246, 1.557)	0	0.485	0
超氧化物歧化酶活性 Activity of SOD	<1.19	7	0.06(?0.447, 0.567)	0.551	0	94.5
超氧化物歧化酶活性 Activity of SOD	≥1.19	3	?1.086 (?2.059, ?0.113)	0.029	0	96.6

Meta-analysis of effects of ionizing radiation on antioxidant enzyme and malondialdehyde levels of occupational population

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