Journal of Radiation Research and Radiation Processing ›› 2019, Vol. 37 ›› Issue (3): 5-030302-6.doi: 10.11889/j.1000-3436.2019.rrj.37.030302

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles     Next Articles

Protective effect of N-oxalyl-D-phenylalanine on radiation injury in mice

MENG Yuanyuan(),XU Wenqing()   

  1. Institute of Radiation Medicine, Chinese Academy of Medical Sciences and
  • Received:2019-01-07 Revised:2019-03-14 Accepted:2019-03-14 Online:2019-06-20 Published:2019-06-18
  • Contact: Wenqing XU E-mail:xiaofanmm@outlook.com;xuwenqing@irm-cams.ac.cn
  • About author:MENG Yuanyuan(female), was born in October 1992, and graduated from Shenyang Pharmaceutical University in 2016. Now she is a master candidate at Institute of Radiation Medicine, Chinese Academy of Medical Sciences, majoring in medical chemistry. E-mail: xiaofanmm@outlook.com
  • Supported by:
    Supported by the Chinese Academy of Medical Sciences Medical Science Innovation Fund(CIFMS, 2017-I2M-3-019)

Abstract:

A small molecule inhibitor of aspartate hydroxylase, also known as hypoxia-inducible factor inhibitor (FIH), and N-oxalyl-D-phenylalanine (NOFD) was synthesized, and a mouse model for drug administration was used to evaluate the radiation protection offered by NOFD. Experimental mice were divided into the groups control, irradiation, and irradiation administration (10,5,2.5 mg/kg for high,middle,low-dose group). The 30-day survival rate, organ index, and peripheral blood component analysis were used to evaluate the protective effect of NOFD on mice after irradiation. The results showed that the 30-day survival rate of mice in the NOFD administration group was significantly higher than that in the simple irradiation group, and that the survival rate of mice treated with the middle dose of NOFD (5 mg/kg) increased by 30%. Moreover, 5 mg/kg NOFD administration not only significantly increased the white blood cell count, red blood cell count, and hemoglobin content in the peripheral blood of mice after irradiation, but also significantly increased the number of spleen clones (p<0.01). Thus, the results suggest that NOFD has a protective effect on irradiated mice.

Key words: N-oxalyl-D-phenylalanine (NOFD), Mice, Radioprotection

CLC Number: 

  • TL71,R979.6