放射性核素Cs+污染伤口的洗消剂研究

doi:10.11889/j.1000-3436.2018.rrj.36.060304

Journal of Radiation Research and Radiation Proces ›› 2018, Vol. 36 ›› Issue (6): 60304-060304.doi: 10.11889/j.1000-3436.2018.rrj.36.060304

• RADIATION CHEMISTRY • Previous Articles Next Articles

Study on decontaminating agent of radionuclide Cs⁺-contaminated wounds

HU Xiuting^1,2, LUO Qun², BAI Shuang^1,2, GAO Chunli^1,2, HE Ying², SHEN Xianrong²

1 Shanghai Ocean University, Shanghai 201306, China;
2 Department of Protection Medicine, Naval Medical Research Institute, The Second Military Medical University, Shanghai 200433, China

Received:2018-08-07 Revised:2018-10-22 Online:2018-12-20 Published:2018-12-21
Supported by:
Supported by Shanghai Natural Science Foundation (16ZR1414200)

Abstract

Abstract:

The aim of the study was to investigate the decontaminating effect of several chelating agents (EDTA·Na₂, DTPA, and EDTMPA) and adsorbents (sodium alginate and carboxymethyl chitosan) on Cs⁺-contaminated wounds. A skin punch was used to establish a model dorsal wound in rats. The stable isotope of radioactive cesium was chosen as the target for wound decontamination. An appropriately concentrated solution of three chelating agents and two adsorbents were used as the decontamination fluid. A disposable surgical lavage system was used to flush the contamination wound, and the flushing fluid was collected. The cesium ion content in the flushing fluid was detected by inductive coupled plasma emission spectrometry, and the decontamination efficiency was calculated. The decontamination efficiency increased with the concentration of EDTA·Na₂; the efficiency of 0.6 mol/L EDTA·Na₂ reached 74.15%, which was significantly higher than that of saline water (p<0.01). The decontamination efficiency increased with the concentration of DTPA, but was not significantly different to that of saline water. With the increase of EDTMPA concentrations, the decontamination efficiency first increased and then appeared to decrease. The decontamination efficiency of 0.01 mol/L EDTMPA reached 76.06%, which was significantly higher than that of saline water (p<0.01). In general, the decontamination efficiency increased with concentrations of sodium alginate and carboxymethyl chitosan. The decontamination efficiency of 3 g/L sodium alginate (68.22%, p<0.05) and 4 g/L carboxymethyl chitosan (74.22%, p<0.01) was significantly different compared with that of saline water. The optimization of the decontamination conditions showed that the decontamination efficiency increased with the contamination volume and decontamination fluid volume, and decreased as the increase of contamination time. We concluded that the chelating agents (EDTA·Na₂ and EDTMPA) and adsorbents (sodium alginate and carboxymethyl chitosan) have a significant decontaminating effect on Cs⁺-contaminated wounds, and have the potential to be developed into a highly efficient decontamination detergent for wound contamination.

Key words: Radionuclide, Cesium ion, Chelating agent, Adsorbent, Rats, Wound decontamination

CLC Number:

R146

HU Xiuting, LUO Qun, BAI Shuang, GAO Chunli, HE Ying, SHEN Xianrong. Study on decontaminating agent of radionuclide Cs⁺-contaminated wounds[J].Journal of Radiation Research and Radiation Proces, 2018, 36(6): 60304-060304.

References

1 原维鸿. 放射性物质污染皮肤和伤口洗消剂的研究[D]. 上海:上海海洋大学, 2018.YUAN Weihong. Study on decontaminants for skin and wound radioactive isotopes contamination[D]. Shanghai:Shanghai Ocean University, 2018.
2 胡晓梅, 叶红. 核辐射及其安全防护[J]. 中国新技术新产品, 2014(16):168. DOI:10.13612/j.cnki.cntp.2014.16.135.HU Xiaomei, YE Hong. Nuclear radiation and its safety protection[J]. New Techonlogy and Products in China, 2014(16):168. DOI:10.13612/j.cnki.cntp.2014.16.135.
3 程艳, 高静, 徐红纳, 等. 螯合剂EDTA简介[J]. 化学教育, 2009(5):4-6. DOI:10.3969/j.issn.1003-3807.2009.05.002.CHENG Yan, GAO Jing, XU Hongna, et al. A brief introduction of EDTA[J]. Chemical Education, 2009(5):4-6. DOI:10.3969/j.issn.1003-3807.2009.05.002.
4 于汋, 安海英. 核应急现场医学救援伤员洗消的实践[J]. 灾害医学与救援(电子版), 2017, 6 (2):109-149. DOI:10.19372/j.cnki.issn.2095-3496.2017.02.012.YU Shao, AN Haiying. Practice of medical rescue in nuclear emergency field[J]. Disaster Medicine and Rescue (Electronic Edition), 2017, 6 (2):109-149. DOI:10.19372/j.cnki.issn.2095-3496.2017.02.012.
5 覃世辉, 黄荣瑢, 张晖英. pH-生成函数法测定乙二胺四亚甲基膦酸的电离常数[J]. 广东化工, 2015, 42 (3):124-126. DOI:10.3969/j.issn.1007-1865.2015.03.064.QIN Shihui, HUANG Rongrong, ZHANG Huiying. Determination of the ethylene diamine tetra methylene acid ionization constants by pH-formation function method[J]. Guangdong Chemical Industry, 2015, 42 (3):124-126. DOI:10.3969/j.issn.1007-1865.2015.03.064.
6 朱梦琪, 郁建平. 多糖伤口清洗剂配方的正交分析法优化[J]. 山地农业生物学报, 2014, 33 (3):25-27/54. DOI:10.15958/j.cnki.sdnyswxb.2014.03.008.ZHU Mengqi, YU Jianping. The optimization of biological polysaccharide wound cleaning reagent by orthogonal analysis[J]. Journal of Mountain Agriculture and Biology, 2014, 33 (3):25-27, 54. DOI:10.15958/j. cnki.sdnyswxb.2014.03.008.
7 王春华, 曲荣君, 孙昌梅, 等. 羧甲基壳聚糖/聚乙烯醇/甘油环氧树脂蛇笼型复合螯合膜的制备及对金属离子的吸附性能[J]. 离子交换与吸附, 2004, 20 (6):494-500. DOI:10.16026/j.cnki.iea.2004.06.002.WANG Chunhua, QU Rongjun, SUN Changmei, et al. Preparation of carboxymethyl Chitosan/polyvinyl alcohol/glycerol epoxy resin snake cage composite chelating membrane and its adsorption properties on metal ions[J]. Ion Exchange and Adsorption, 2004, 20 (6):494-500. DOI:10.16026/j.cnki.iea.2004.06.002.
8 张华, 王子卫, 廖刚, 等. 高渗出性伤口的研究进展[J]. 中华现代护理杂志, 2012, 18 (36):4456-4457. DOI:10.3760/cma.j.issn.1674-2907.2012.36.043.ZHANG Hua, WANG Ziwei, LIAO Gang, et al. Research progress on high exudative wound[J]. Chinese Journal of Modern Nursing, 2012, 18 (36):4456-4457. DOI:10.3760/cma.j.issn.1674-2907.2012.36.043.
9 吴伟英, 陈影洁, 黄剑施, 等. 联合清创在糖尿病足溃疡中的应用[J]. 中华现代护理杂志, 2011, 17 (35):4272-4273. DOI:10.3760/cma.j.issn.1674-2907.2011.35.008.WU Weiying, CHEN Yingjie, HUANG Jianshi, et al. The application of combined debridement in diabetic foot ulcers[J]. Chinese Journal of Modern nursing, 2011, 17 (35):4272-4273. DOI:10.3760/cma.j.issn.1674-2907.2011.35.008.
10 徐晓平. 门诊输液护理体会[J]. 基层医学论坛, 2013, 17 (15):2037-2038. DOI:10.3969/j.issn.1672-1721.2013.15.106.XU Xiaoping. Experience of transfusion nursing in outpatient clinic[J]. The Medical Forum, 2013, 17 (15):2037-2038. DOI:10.3969/j.issn.1672-1721.2013.15.106.
11 Hsampanpanis P, Pinpa K. Cadmium removal from contaminated sediment using EDTA and DTPA with water hyacinth[J]. International Journal of Environmental Research, 2018, 12 (4):543-551. DOI:10.1007/s41742-018-0114-y.
12 刘春英, 柳云骐, 周欣明, 等. 造纸助剂二乙烯三胺五乙酸的合成研究[J]. 精细石油化工进展, 2011, 12 (11):50-53. DOI:10.3969/j.issn.1009-8348.2011.11.013.LIU Chunying, LIU Yunqi, ZHOU Xinming, et al. Synthesis of diethylenetriaminepentaacetic acid as papermaking additive[J]. Advances in Fine Petrochemicals, 2011, 12 (11):50-53. DOI:10.3969/j.issn. 1009-8348.2011.11.013.
13 赵先英, 舒为群, 曹佳, 等. 医院污水中放射性物质排放状况研究[J]. 西南国防医药, 2005, 15 (1):29-31. DOI:10.3969/j.issn.1004-0188.2005.01.012.ZHAO Xianying, SHU Weiqun, CAO Jia, et al. Investigation of discharge conditions of radioactive substances in hospital sewerage[J]. Southwest National Defense Medicine, 2005, 15 (1):29-31. DOI:10.3969/j. issn.1004-0188.2005.01.012.
14 Contreras A E, Steiner Z. Studying the role of common membrane surface functionalities on adsorption and cleaning of organic foulants using QCM-D[J]. Environmental Science & Technology, 2011, 45:6309-6315.
15 吴慧玲. 海藻酸钠纳米复合材料的研究应用进展[J].化工进展, 2014, 30 (4):136-140. DOI:10.3969/j.issn. 1000-6613.2014.04.028.WU Huiling. Progress in research and application of sodium alginate nanocomposites[J]. Progress in Chemical Industry, 2014, 30 (4):136-140. DOI:10.3969/j.issn. 1000-6613.2014.04.028.

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Study on decontaminating agent of radionuclide Cs⁺-contaminated wounds