槲皮素促进电离辐射引起的衰老细胞发生凋亡

doi:10.11889/j.1000-3436.2019.rrj.37.060302

Journal of Radiation Research and Radiation Processing ›› 2019, Vol. 37 ›› Issue (6): 26-33.doi: 10.11889/j.1000-3436.2019.rrj.37.060302

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles Next Articles

Quercetin promotes apoptosis in ionizing radiation-induced senescent cells

LONG Kaiqin^1,²,HE Jinpeng²,ZHANG Tongshan^2,³,MA Wei^2,³,HUA Junrui²,WANG Jufang²()

1. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
2. Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Science, Lanzhou 730000, China
3. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2019-08-28 Revised:2019-10-12 Accepted:2019-10-12 Online:2019-12-20 Published:2019-12-23
Contact: WANG Jufang E-mail:jufangwang@impcas.ac.cn
About author:LONG Kaiqin(female) was born in September 1993, and graduated from Sichuan University in 2017. Now she is a master candidate at Lanzhou University, majoring in radiation pharmacology
Supported by:
National Natural Science Foundation of China(U1232125);Gansu Science and Technology Program Project(145RTSA012)

1	Di M D, Alimonti A. Non-cell-autonomous regulation of cellular senescence in cancer[J]. Trends in Cell Biology, 2016, 26(3): 215-226. DOI:10.1016/j.tcb.2015.10.005. doi: 10.1016/j.tcb.2015.10.005
2	Childs B G, Baker D J, Kirkland J L, et al. Senescence and apoptosis: dueling or complementary cell fates?[J]. EMBO Reports, 2014, 15(11): 1139-1153. DOI: 10.15252/embr.201439245. doi: 10.15252/embr.201439245
3	Hernandez-Segura A, Nehme J, Demaria M. Hallmarks of cellular senescence[J]. Trends in Cell Biology, 2018, 28(6): 436-453. DOI: 10.1016/j.tcb.2018.02.001. doi: 10.1016/j.tcb.2018.02.001
4	Milanovic M, Fan D, Belenki D, et al. Senescence-associated reprogramming promotes cancer stemness[J]. Nature, 2017, 553(7686): 96-100. DOI:0.1038/nature25167. doi: 0.1038/nature25167
5	Kamada T, Tsujii H, Blakely E A, et al. Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience[J]. The Lancet Oncology, 2015, 16(2): e93-e100. DOI: 10.1016/S1470-2045(14)70412-7. doi: 10.1016/S1470-2045(14)70412-7
6	Zhang X R, Ye C Y, Sun F, et al. Both complexity and location of DNA damage contribute to cellular senescence induced by ionizing radiation[J]. PLoS One, 2016, 11(5): e0155725. DOI: 10.1371/journal.pone.0155725. doi: 10.1371/journal.pone.0155725
7	Sieben C J, Sturmlechner I, van de Sluis B, et al. Two-step senescence-focused cancer therapies[J]. Trends in Cell Biology, 2018, 28(9): 723-737. DOI: 10.1016/j.tcb.2018.04.006. doi: 10.1016/j.tcb.2018.04.006
8	Vassilios M, Konstantinos E, Vasileiou P V S, et al. Senescence and senotherapeutics: a new field in cancer therapy[J]. Pharmacology & Therapeutics, 2019, 193: 31-49. DOI: 10.1016/j.pharmthera.2018.08.006. doi: 10.1016/j.pharmthera.2018.08.006
9	Rudin C M, Hann C L, Garon E B, et al. Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer[J]. Clinical Cancer Research, 2012, 18(11): 3163-3169. DOI: 10.1158/1078-0432.CCR-11-3090. doi: 10.1158/1078-0432.CCR-11-3090
10	Kipps T J, Eradat H, Grosicki S, et al. A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia[J]. Leukemia and Lymphoma, 2015, 56(10): 2826-2833. DOI: 10.3109/10428194.2015.1030638. doi: 10.3109/10428194.2015.1030638
11	骆明旭, 罗丹，赵万红. 槲皮素药理作用研究进展[J]. 中国民族民间医药, 2014, 17:12-14. DOI: 10.3969/j.issn.1001-6880.2003.02.023. doi: 10.3969/j.issn.1001-6880.2003.02.023
	LUO Mingxu, LUO Dan, ZHAO Wanhong. Research progress on pharmacological action of quercetin[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2014, 17: 12-14. DOI: 10.3969/j.issn.1001-6880.2003.02.023. doi: 10.3969/j.issn.1001-6880.2003.02.023
12	Ming X, Tamar P, Joshua N F, et al. Senolytics improve physical function and increase lifespan in old age[J]. Nature Medicine, 2018, 24(8): 1246-1256. DOI: 10.1038/s41591-018-0092-9. doi: 10.1038/s41591-018-0092-9
13	Ana B G S, María A M, Bravo L, et al. Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2)[J]. Journal of Nutrition, 2006, 136(11): 2715-2721. DOI: 10.1093/jn/136.11.2715. doi: 10.1093/jn/136.11.2715
14	Granato M, Rizzello C, Gilardini Montani M S, et al. Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways[J]. Journal of Nutritional Biochemistry, 2017, 41: 124-136. DOI: 10.1016/j.jnutbio.2016.12.011. doi: 10.1016/j.jnutbio.2016.12.011
15	张栩锐. 重离子辐射诱发细胞早熟性衰老的机理研究[D]. 兰州: 中国科学院近代物理研究所, 2016.
	ZHANG Xurui. The mechanisms of premature cellular senescence induced by heavy ion radiation[D]. Lanzhou: Institute of Modern Physics, Chinese Academy of Sciences. 2016.
16	Nguyen H Q, To N H, Zadigue P, et al. Ionizing radiation-induced cellular senescence promotes tissue fibrosis after radiotherapy. A review[J]. Critical Reviews in Oncology/Hematology, 2018, 129: 13-26. DOI: 10.1016/j.critrevonc.2018.06.012. doi: 10.1016/j.critrevonc.2018.06.012
17	Rodier F, Campisi J. Four faces of cellular senescence[J]. Journal of Cell Biology, 2011, 192(4): 547-56. DOI: 10.1083/jcb.201009094. doi: 10.1083/jcb.201009094
18	Kirkland J L, Tchkonia T. Clinical strategies and animal models for developing senolytic agents[J]. Experimental Gerontology, 2015, 68: 19-25. DOI: 10.1016/j.exger.2014.10.012. doi: 10.1016/j.exger.2014.10.012
19	Eok-Cheon K, Jae-Ryong K. Senotherapeutics: emerging strategy for healthy aging and age-related disease[J]. BMB Reports, 2019, 52(1): 47-55. DOI: 10.5483/BMBRep.2019.52.1.293. doi: 10.5483/BMBRep.2019.52.1.293
20	Douglas R G. The coming decade of cell death research: five riddles[J]. Cell, 2019, 177(5): 1094-1107. DOI: 10.1016/j.cell.2019.04.024. doi: 10.1016/j.cell.2019.04.024
21	Kovacovicova K, Skolnaja M, Heinmaa M, et al. Senolytic cocktail dasatinib+quercetin (D+Q) does not enhance the efficacy of senescence-inducing chemotherapy in liver cancer[J]. Frontiers in Oncology, 2018, 8: 459. DOI: 10.3389/fonc.2018.00459. doi: 10.3389/fonc.2018.00459
22	Liu X H, Zhao Y H, Zhang W N, et al. Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis[J]. OncoTargets and Therapy, 2018, 11: 3087-3100. DOI: 10.2147/OTT.S166798. doi: 10.2147/OTT.S166798
23	Sundaram M K, Raina R, Afroze N, et al. Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells[J]. Bioscience Reports, 2019, 39(8): BSR20190720. DOI: 10.1042/BSR20190720. doi: 10.1042/BSR20190720
24	Martin F, Marianne Q, Lydia S. The p53-p21-DREAM-CDE/CHR pathway regulates G₂/M cell cycle genes[J]. Nucleic Acids Research, 2016, 44(1): 164-174. DOI: 10.1093/nar/gkv927. doi: 10.1093/nar/gkv927
25	Erik M, Helena S, Cascales K B. Residual Cdk1/2 activity after DNA damage promotes senescence[J]. Aging Cell, 2017, 16(3): 575-584. DOI: 10.1111/acel.12588. doi: 10.1111/acel.12588
26	He J P, Li J H, Ye C Y, et al. Cell cycle suspension: a novel process lurking in G₂ arrest[J]. Cell Cycle, 2011, 10(9): 1468-1476. DOI: 10.4161/cc.10.9.15510. doi: 10.4161/cc.10.9.15510
27	Johmura Y, Shimada M, Misaki T. Necessary and sufficient role for a mitosis skip in senescence induction[J]. Molecular Cell, 2014, 55(1): 73-84. DOI: 10.1016/j.molcel.2014.05.003. doi: 10.1016/j.molcel.2014.05.003

[1]	YANG Yuhong,LI Na. Bioinformatic analysis of differentially expressed genes in tumor-associated fibroblasts after ionizing radiation [J]. Journal of Radiation Research and Radiation Processing, 2020, 38(1): 32-41.
[2]	LU Zhaoxiang,WANG Jinhui,XU Ning,LUAN Jie,PANG Xiangyu,XIA Yujun. Protective effect of compound raspberry seed powder on radiation-induced spinal cord injury in mice [J]. Journal of Radiation Research and Radiation Processing, 2020, 38(1): 42-49.
[3]	BAI Hao,WEI Wenjun,WANG Jufang,MA Wei. Study on radio-sensitive proteins to ionizing radiation in mice serum [J]. Journal of Radiation Research and Radiation Processing, 2019, 37(6): 18-25.
[4]	NAI Aitao, WANG Zhen, LUO Dan, WANG Yixuan, WAN Wei, CAO Wenyu, HE Jie, CHEN Xi, HE Shuya, WANG Wuzhou, XU Yang, AI Xiaohong. Ionizing radiation induces cognitive dysfunction by activating prefrontal cortex NLRP3 inflammasome in mice [J]. Journal of Radiation Research and Radiation Processing, 2019, 37(4): 2-040301-8.
[5]	YANG Yu WANG Xianghui QI Hongxing ZHANG Jie. Apoptotic effect of wide-band electromagnetic pulse on epithelial cells [J]. Journal of Radiation Research and Radiation Processing, 2019, 37(4): 3-040302-8.
[6]	WANG Qingrong HE Ying ZHAO Yining SHEN Xianrong LIU Yuming LI Kexian. Effect of cimetidine on spleen cell apoptosis and expression of apoptosis-related proteins in Beagle dogs exposed to low-dose-rate radiation [J]. Journal of Radiation Research and Radiation Processing, 2019, 37(4): 6-040305-7.
[7]	GAO Chunli, SHI Te, ZHANG Junling, SHEN Xianrong, HE Ying, WANG Qingrong. Protective effects of Sipunculus nudus polysaccharide on radiation damage in human intestinal epithelial cells [J]. Journal of Radiation Research and Radiation Processing, 2019, 37(3): 4-030301-9.
[8]	LIU Liangli, CHEN Xianglan, FENG Shuidong. Meta-analysis of effects of ionizing radiation on antioxidant enzyme and malondialdehyde levels of occupational population [J]. Journal of Radiation Research and Radiation Processing, 2019, 37(3): 7-030701-11.
[9]	WANG Zhen,LUO Shishi,NIU Lei,NAI Aitao,XU Yang,LIU Zhenghai,HE Jie,HE Shuya,ZHONG Xiaolin,WAN Wei,CAO Wenyu. Ionizing radiation induces cognitive dysfunction by activating hippocampal astrocytes in mice [J]. Journal of Radiation Research and Radiation Processing, 2019, 37(1): 10301-010301.
[10]	TANG Liyun, NAI Aitao, WANG Zhen, XU Yang, LIU Zhenghai, HE Jie, CHEN Xi, HE Shuya, ZHONG Xiaolin, TANG Yinjuan, WAN Wei, AI Xiaohong, CAO Wenyu. Environmental enrichment improves irradiation-induced cognitive dysfunction [J]. Journal of Radiation Research and Radiation Proces, 2018, 36(6): 60201-060201.
[11]	NAI Aitao, WANG Zhen, TANG Liyun, WAN Wei, LIU Zhenghai, XU Yang, AI Xiaohong, HE Shuya, CAO Wenyu. Effects of gamma-ray irradiation on cognitive function and neuronal death in mice [J]. Journal of Radiation Research and Radiation Proces, 2018, 36(5): 50202-050202.
[12]	WANG Lei, ZHONG Yuan, HE Mingyan, HUANG Bo, RANG Weiqing. Meta-analysis of effects of low-dose ionizing radiation on peripheral hemocytes of occupational population [J]. Journal of Radiation Research and Radiation Proces, 2018, 36(3): 30501-030501.
[13]	YU Peixun, YUAN Wei, MENG Qinglan. Protective effect of compound raspberry seed powder on bone marrow cells of irradiated mice [J]. Journal of Radiation Research and Radiation Proces, 2018, 36(2): 20202-020202.
[14]	HE Ying, ZHANG Junling, ZHAO Yining, JIANG Dingwen, WANG Qingrong, LI Kexian, LUO Qun, SHEN Xianrong. Protective effect of cimetidine on immune function of mice irradiated by gamma-rays [J]. Journal of Radiation Research and Radiation Proces, 2018, 36(2): 20203-020203.
[15]	QI Guangxia, ZHANG Xi, ZHANG Simeng, LI Lei, WANG Bangda, REN Lianhai, WANG Yi, WANG Wei. Degradation of orange Ⅱ by “γ ray-BaF₂-nano TiO₂” radiocatalysis system [J]. Journal of Radiation Research and Radiation Proces, 2017, 35(6): 60301-060301.

Quercetin promotes apoptosis in ionizing radiation-induced senescent cells

RichHTML

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 4

References 27

Related Articles 15

Metrics

Comments

Recommended 10