Journal of Radiation Research and Radiation Processing ›› 2019, Vol. 37 ›› Issue (6): 1-7.doi: 10.11889/j.1000-3436.2019.rrj.37.060101

• REVIEW •     Next Articles

A review of the relationship of reactive oxygen species with radiation-induced lung injuries

LI Chengcheng1,ZHANG Qiuning2,WANG Xiaohu1,2()   

  1. 1. The First School of Clinical Medicine, Lanzhou University,Lanzhou 730000,China
    2. Gansu Provincial Cancer Hospital,Lanzhou 730050,China
  • Received:2019-05-16 Revised:2019-09-20 Accepted:2019-09-20 Online:2019-12-20 Published:2019-12-23
  • Contact: WANG Xiaohu
  • About author:LI Chengcheng(female) was born in February 1991, and obtained her bachelor's degree from Shandong First Medical University in 2014. Now she is a doctoral candidate at Lanzhou University
  • Supported by:
    Lanzhou Innovation and Entrepreneurship Talents Project(Research on Key Technologies of Basic and Clinical Application of Domestic Heavy Ion Accelerator in Treating Cancer 2017-RC-23)


Radiation-induced lung injury (RILI) is a highly complex complication that can occur due to radiation therapy of thoracic tumors, bone marrow transplantation, and pretreatment with nuclear radiation, including acute radiation pneumonia and chronic radiation-induced pulmonary with fibrosis. The degree of RILI is related to the fractionation mode, dose distribution, V20, and pulmonary function of patients. The main manifestations of RILI are dry cough, chest tightness, chest pain and low fever, even dyspnea. Antibiotic therapy is ineffective. RILI has a high mortality rate and impacts patients’ quality of life. Currently, the pathogenesis of RILI mainly involves target cells, cytokines, immunoreaction, and the oxidative stress theory. We will review the research that focusses on the role of reactive oxygen species in the cytokine and oxidative stress theories as well as related RILI and correlative precaution measures.

Key words: Reactive oxygen species, Radiation-induced lung injury, Review

CLC Number: 

  • R73