Journal of Radiation Research and Radiation Processing ›› 2019, Vol. 37 ›› Issue (5): 1-050101-10.doi: 10.11889/j.1000-3436.2019.rrj.37.050101

• REVIEW •     Next Articles

Application of framework nucleic acids in biochemical detection

XIE Mo1,2(),GU Peilin1,2,LI Yu1,2,LIU Huajie4,WANG Lihua1,3()   

  1. 1. Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
    3. Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China
    4. School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China
  • Received:2019-04-01 Revised:2019-04-28 Accepted:2019-04-28 Online:2019-10-20 Published:2019-10-15
  • Contact: Lihua WANG;
  • About author:XIE Mo(female) was born in November 1989, and obtained her bachelor’s degree from Hubei University in 2012. Now she is a doctoral candidate at Shanghai Institute of Applied physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences. E-mail:
  • Supported by:
    the National Key R&D Program of China(2016YFA0201200);National Natural Science Foundation of China(21675167)


Nucleic acids are biomolecules that are carriers of genetic information using which several micro and macro structures are constructed. Framework nucleic acids (FNAs), which are synthesized via nucleic acid self-assembly and widely used in chemistry, biomedicine, radiation biochemistry, and other fields, are novel nanostructures designed and controlled at the nanoscale. Imaging technologies play a crucial role in intuitively visualizing the structure and function of FNAs. Here, the structure and imaging technology for FNAs are reviewed, and the application of FNAs in biochemical detection, especially detection of ionizing radiation, and their developmental prospects are summarized.

Key words: Framework nucleic acids, DNA nanotechnology, DNA origami, Imaging technology, Biochemical detection

CLC Number: 

  • O651