电离辐射对人舌鳞癌CAL-27细胞影响的生物信息学分析

doi:10.11889/j.1000-3436.2019.rrj.37.040304

Journal of Radiation Research and Radiation Processing ›› 2019, Vol. 37 ›› Issue (4): 5-040304-7.doi: 10.11889/j.1000-3436.2019.rrj.37.040304

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles Next Articles

Bioinformatic analysis of ionizing radiation on CAL-27 cells

HU Songling^1,²(),HU Qingling⁴,WANG Weiping²,HE Xiangyi²,DANG Bingrong³,SHAO Chunlin¹()

1. Institute of Radiation Medicine, Fudan University, Shanghai 200032, China
2. School of Stomatology, Lanzhou University, Lanzhou 730000, China
3. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
4. Dezhou City People's Hospital, Dezhou 253000, China

Received:2018-12-24 Revised:2019-02-27 Accepted:2019-02-27 Online:2019-08-20 Published:2019-08-21
Contact: Chunlin SHAO E-mail:18111140002@fudan.edu.cn;clshao@shmu.edu.cn
About author:HU Songling(female) was born in July 1987, and graduated from Lanzhou University in 2017. Now she is a doctoral candidate at Fudan University, majoring in radiation medicine. E-mail: 18111140002@fudan.edu.cn
Supported by:
the National Key R&D Program of China (2017YFC0108604) and National Natural Science Foundation of China(11179002)

小RNA名称

miRNA name

X08标准差

X08 standard

deviation

R08标准差

R08 standart

deviation

倍数变化

FC(lg2 (R08/X08))

上调/下调

Up/down expression

p值

p value

hsa-miR-629-5p

11.166

56.504

2.339

上调Up

5.04×10^-94

hsa-miR-146b-5p

144.272

624.576

2.114

上调Up

hsa-miR-15b-5p

74.685

253.859

1.765

上调Up

3.17×10^-289

hsa-miR-193b-3p

57.288

183.655

1.681

上调Up

5.28×10^-196

hsa-miR-24-3p

74.766

223.793

1.582

上调Up

1.02×10^-218

hsa-let-7b-5p

449.969

1 345.275

1.580

上调Up

hsa-miR-23b-3p

35.764

98.048

1.455

上调Up

6.42×10^-86

hsa-miR-873-3p

49.844

124.708

1.323

上调Up

1.90×10^-94

hsa-miR-30c-5p

390.820

974.188

1.318

上调Up

hsa-miR-197-3p

30.181

67.834

1.168

上调Up

2.83×10^-43

hsa-miR-190a-5p

8.415

18.069

1.102

上调Up

1.17×10^-11

hsa-let-7g-5p

646.592

1 304.545

1.013

上调Up

hsa-miR-181a-2-3p

717.797

352.722

-1.025

下调Down

hsa-miR-130a-3p

446.004

216.017

-1.046

下调Down

3.68×10^-232

hsa-miR-181a-3p

721.034

345.909

-1.060

下调Down

hsa-miR-30a-5p

49 327.014

23 308.890

-1.082

下调Down

hsa-miR-30c-2-3p

739.482

343.983

-1.104

下调Down

hsa-miR-4746-5p

34.227

15.329

-1.159

下调Down

1.26×10^-22

hsa-miR-454-5p

57.369

25.030

-1.197

下调Down

1.14×10^-38

hsa-miR-3614-5p

136.504

55.615

-1.295

下调Down

3.10×10^-101

hsa-miR-210-3p

35.926

14.144

-1.345

下调Down

1.75×10^-29

hsa-miR-3615

180.441

69.167

-1.383

下调Down

3.29×10^-147

hsa-miR-100-3p

262.893

97.382

-1.433

下调Down

3.82×10^-225

hsa-miR-21-3p

2 968.287

1 011.733

-1.553

下调Down

hsa-miR-149-5p

26.864

7.554

-1.830

下调Down

2.58×10^-34

hsa-miR-92b-3p

15 202.477

4 014.719

-1.921

下调Down

hsa-miR-1304-3p

1 897.781

468.617

-2.018

下调Down

hsa-miR-221-5p

128.736

28.807

-2.160

下调Down

3.80×10^-196

hsa-miR-1286

56.883

12.071

-2.236

下调Down

1.44×10^-91

hsa-miR-1285-3p

113.524

22.068

-2.363

下调Down

2.08×10^-193

hsa-miR-937-3p

50.734

8.738

-2.537

下调Down

5.61×10^-95

hsa-miR-1910-5p

320.424

49.617

-2.691

下调Down

hsa-miR-877-5p

1 068.968

162.846

-2.715

下调Down

信号通路名称 Pathway name	注释的靶基因通路数量(29 296) Target genes with pathway annotation (29 296)	P值 p value	信号通路编号 Pathway ID
嗅觉传导通路 Olfactory transduction	517	2.21×10^-17	ko04740
细胞因子受体交互通路 Cytokine-cytokine receptor interaction	532	5.78×10^-8	ko04060
丝裂原活化蛋白激酶 Mitogen-activated protein kinases	100	1.283×10^-4	ko04011
氯代烷和氯代烷烃的降解 Chloroalkane and chloroalkene degradation	34	2.232×10^-4	ko00625
病毒性心肌炎 Viral myocarditis	528	2.593×10^-4	ko05416
移植排斥反应 Allograft rejection	112	6.248×10^-4	ko05330
类风湿性关节炎 Rheumatoid arthritis	279	9.31×10^-4	ko05323
自身免疫性甲状腺疾病 Autoimmune thyroid disease	134	1.0224×10^-3	ko05320
金黄色葡萄球菌感染 Staphylococcus aureus infection	269	1.0305×10^-3	ko05150
肺结核 Tuberculosis	614	2.4105×10^-3	ko05152
霍乱弧菌感染 Vibrio cholerae infection	345	2.5335×10^-3	ko05110
I型糖尿病 Type I diabetes mellitus	116	2.8523×10^-3	ko04940
真核生物核糖体的生物合成 Ribosome biogenesis in eukaryotes	180	3.4748×10^-3	ko03008
哮喘 Asthma	73	3.844×10^-3	ko05310
肾素-血管紧张素系统 Renin-angiotensin system	30	4.547×10^-3	ko04614

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Bioinformatic analysis of ionizing radiation on CAL-27 cells

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