Journal of Radiation Research and Radiation Processing ›› 2019, Vol. 37 ›› Issue (3): 7-030701-11.doi: 10.11889/j.1000-3436.2019.rrj.37.030701

• RADIATION INTERDISCIPLINARY RESEARCH • Previous Articles     Next Articles

Meta-analysis of effects of ionizing radiation on antioxidant enzyme and malondialdehyde levels of occupational population

LIU Liangli(),CHEN Xianglan,FENG Shuidong()   

  1. School of Public Health, University of South China, Hengyang 421001, China
  • Received:2019-01-08 Revised:2019-03-21 Accepted:2019-03-21 Online:2019-06-20 Published:2019-06-18
  • Contact: Shuidong FENG E-mail:879004657@qq.com;shuidong_f@hotmail.com
  • About author:LIU Liangli (female) was born in March 1993, and graduated from Chuanshan College, University of South China in 2016. Now she is a master candidate at University of South China, majoring in public health. E-mail: 879004657@qq.com
  • Supported by:
    Supported by Natrual Science Foundation of Hunan Province(2018JJ2342)

Abstract:

In order to review the influence of ionizing radiation on antioxidant enzyme activity and malondialdehyde (MDA) levels, relevant literatures databases, such as the China National Knowledge Infrastructure (CNKI), VIP database, Wanfang database, The Cochrane Library, Web of Science, Pubmed, and EMbase, were searched until September 2018. Two reviewers independently screened these papers and evaluated the risk of bias. The extracted data were analyzed using Stata 12.0 software. A total of 14 literatures involving 1 733 radiation workers and 1 796 controls were included. The results of meta-analysis showed that the level of malondialdehyde and the activity of superoxide dismutase increased in the exposed than in the unexposed group (SMD=1.284, 95% CI: 0.74~1.828, p=0; SMD=0.681, 95% CI: 0.056~1.306, p=0.033), while there was no statistical significance observed in the activity of glutathione peroxidase and catalase, respectively (SMD=?0.106, 95% CI: ?0.458~0.246, p=0.554; SMD=1.175, 95% CI: ?0.331~2.681, p=0.126). The subgroup analysis stratified by work showed that compared with the unexposed group, the level of malondialdehyde was increased in themedical, industrial detecting and other groups, while the activity of superoxide dismutase was increased in medical group but decreased in industrial detecting group. The subgroup analysis stratified by work year showed that, compared with the unexposed group, the level of malondialdehyde and the activity of superoxide dismutase were increased in groups whose work age was higher than 12.56 a. While the subgroup analysis stratified by annual effective dose showed that, compared with the unexposed group, the level of malondialdehyde was increased in all groups and the activity of superoxide dismutase was decreased in groups whose dose was higher than 1.19 mSv/a. The results indicate that ionizing radiation can cause damage of lipid peroxidation with increased malondialdehyde; however its influence on antioxidant enzymes still needs further research.

Key words: Ionizing radiation, Antioxidant enzyme, Malondialdehyde, Occupational exposure

CLC Number: 

  • R148,TL7