Journal of Radiation Research and Radiation Proces ›› 2018, Vol. 36 ›› Issue (6): 60304-060304.doi: 10.11889/j.1000-3436.2018.rrj.36.060304

• RADIATION CHEMISTRY • Previous Articles     Next Articles

Study on decontaminating agent of radionuclide Cs+-contaminated wounds

HU Xiuting1,2, LUO Qun2, BAI Shuang1,2, GAO Chunli1,2, HE Ying2, SHEN Xianrong2   

  1. 1 Shanghai Ocean University, Shanghai 201306, China;
    2 Department of Protection Medicine, Naval Medical Research Institute, The Second Military Medical University, Shanghai 200433, China
  • Received:2018-08-07 Revised:2018-10-22 Online:2018-12-20 Published:2018-12-21
  • Supported by:

    Supported by Shanghai Natural Science Foundation (16ZR1414200)

Abstract:

The aim of the study was to investigate the decontaminating effect of several chelating agents (EDTA·Na2, DTPA, and EDTMPA) and adsorbents (sodium alginate and carboxymethyl chitosan) on Cs+-contaminated wounds. A skin punch was used to establish a model dorsal wound in rats. The stable isotope of radioactive cesium was chosen as the target for wound decontamination. An appropriately concentrated solution of three chelating agents and two adsorbents were used as the decontamination fluid. A disposable surgical lavage system was used to flush the contamination wound, and the flushing fluid was collected. The cesium ion content in the flushing fluid was detected by inductive coupled plasma emission spectrometry, and the decontamination efficiency was calculated. The decontamination efficiency increased with the concentration of EDTA·Na2; the efficiency of 0.6 mol/L EDTA·Na2 reached 74.15%, which was significantly higher than that of saline water (p<0.01). The decontamination efficiency increased with the concentration of DTPA, but was not significantly different to that of saline water. With the increase of EDTMPA concentrations, the decontamination efficiency first increased and then appeared to decrease. The decontamination efficiency of 0.01 mol/L EDTMPA reached 76.06%, which was significantly higher than that of saline water (p<0.01). In general, the decontamination efficiency increased with concentrations of sodium alginate and carboxymethyl chitosan. The decontamination efficiency of 3 g/L sodium alginate (68.22%, p<0.05) and 4 g/L carboxymethyl chitosan (74.22%, p<0.01) was significantly different compared with that of saline water. The optimization of the decontamination conditions showed that the decontamination efficiency increased with the contamination volume and decontamination fluid volume, and decreased as the increase of contamination time. We concluded that the chelating agents (EDTA·Na2 and EDTMPA) and adsorbents (sodium alginate and carboxymethyl chitosan) have a significant decontaminating effect on Cs+-contaminated wounds, and have the potential to be developed into a highly efficient decontamination detergent for wound contamination.

Key words: Radionuclide, Cesium ion, Chelating agent, Adsorbent, Rats, Wound decontamination

CLC Number: 

  • R146