Journal of Radiation Research and Radiation Proces ›› 2018, Vol. 36 ›› Issue (2): 20202-020202.doi: 10.11889/j.1000-3436.2018.rrj.36.020202

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles     Next Articles

Protective effect of compound raspberry seed powder on bone marrow cells of irradiated mice

YU Peixun1, YUAN Wei2, MENG Qinglan1   

  1. 1. Department of Human Anatomy, Qingdao University Medical College, Qingdao 266021, China;
    2. School of Life Science, Qingdao University, Qingdao 266021, China
  • Received:2018-01-18 Revised:2018-02-28 Online:2018-04-20 Published:2018-04-19

Abstract:

This study explores the protective effect of compound raspberry seed powder on the bone marrow cells of acute radiation-injured mice. In the experiment, an acute radiation injury model was generated in mice. A blank control group, a model control group, and treatment groups of different concentrations of compound raspberry seed powder solution (low/medium/high dose group) were established. After irradiation, the changes in nucleus cells, micronucleus rate, cell cycle, and mitochondrial membrane potential of mice bone marrow cells were measured. Compared with the blank control group, the model control group and treatment groups were significantly different (p<0.01).Compared with the model control group, the number of nucleated cells increased by 78.2% (p<0.01) and 116.9% (p<0.01), respectively, in the medium, and high dose groups, and the micronucleus rate in the high dose group decreased by 27.3% (p<0.01). The proportion of cells in the G1 phase and S phase in the medium dose group and in the S phase of high dose group was increased (p<0.05). The proportion of cells in the G1 phase of the high dose group increased significantly (p<0.01). The mitochondrial membrane potential of bone marrow cells in the medium and high dose groups was significantly increased (p<0.01). The results indicated that compound raspberry seed powder increased the number of bone marrow cells, reduced the micronucleus rate, increased the mitochondrial membrane potential, reduced cell cycle arrest, and inhibited the induction of apoptosis by irradiation damage in bone marrow cells, which suggested that compound raspberry seed powder may play an important role in the protection of bone marrow cells injured by irradiation.

Key words: Acute radiation injury, Compound raspberry seed powder, Bone marrow cells, Injury, Apoptosis, Radiation protection

CLC Number: 

  • R81