Journal of Radiation Research and Radiation Proces ›› 2018, Vol. 36 ›› Issue (1): 10101-010101.doi: 10.11889/j.1000-3436.2018.rrj.36.010101

• REVIEW •     Next Articles

Research progress of hypoxia-inducible factor and radiation-induced intestinal injury

DU Jicong, CAI Jianming   

  1. Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China
  • Received:2017-12-13 Revised:2018-01-15 Online:2018-02-20 Published:2018-02-08
  • Supported by:

    Supported by National Natural Science Foundation of China (No.11635014)

Abstract:

Patients with abdominal and pelvic tumors may receive radiotherapy which would cause injury to normal intestinal tissue cells. Recent studies demonstrated that increased hypoxia-inducible factor (HIF) can protect the intestinal tissue from radiation-induced damage. Mechanically, increased HIF could reduce the damage of intestinal epithelial cells and intestinal crypt stem cells to maintain the integrity of epithelial barrier, protecting the intestinal microvascular endothelium cells via up-regulating the expression of vascular endothelial growth factor. Moreover, the up-regulated HIF reduced inflammatory response by regulating the nuclear translocation of NF-kB, the secretion of inflammatory cytokines, and the function of dendritic cells. The relationship between HIF and tumor was also discussed.

Key words: Hypoxia-inducible factor, Radiation-induced intestinal injury, Tumor

CLC Number: 

  • TL7