Journal of Radiation Research and Radiation Proces ›› 2017, Vol. 35 ›› Issue (5): 50201-050201.doi: 10.11889/j.1000-3436.2017.rrj.35.050201

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles     Next Articles

Synthesis and anti-irradiation activities of N-acetyl-S-allyl-L-cysteine

MU Gan'en, LONG Wei, LI Yuanyuan, YU Guangyun, SHEN Xiu, ZHOU Zewei   

  1. Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
  • Received:2017-05-22 Revised:2017-07-15 Online:2017-10-20 Published:2017-10-20
  • Supported by:

    Supported by Tianjin Application Foundation and Research in Cutting-edge Technologies Program (15JCZDJC33400)

Abstract:

The N-acetyl-S-allyl-L-cysteine (NAc-SAC) was synthesized by substitution and acylation reactions with L-cysteine as raw materials. Experiments on blood and immune-organs indexes, and survival rates of ICR mice within 30 d after 137Csγ-rays irradiation at different doses, as well as the comet assay were carried out to investigate the anti-irradiation effects of NAc-SAC. The survival rates of mice irradiated at 7.5 Gy with the dose of NAc-SAC at 200 mg/kg, 400 mg/kg, and 600 mg/kg increased to 58.3%, 50.0% and 66.7%, respectively, and the average survival time was significantly prolonged compared with that in the control group. The spleen indexes, colony forming cell-spleen (CFU-S), percentages of DNA, number of white blood cells of mice irradiated at 6.0 Gy increased under the action of NAc-SAC. The tail length, tail moment, olive tail moment, and tail DNA percentage of peripheral blood lymphocytes of mice irradiated at 7.0 Gy combined with NAc-SAC were higher than those for the control group (p<0.05). To conclude, NAc-SAC has a protective effect against damage induced by irradiation.

Key words: N-acetyl-S-allyl-L-cysteine (NAc-SAC), Radiation protection agent, Mice, Anti-radiation activity, 137Cs γ-rays

CLC Number: 

  • TL7