Journal of Radiation Research and Radiation Proces ›› 2017, Vol. 35 ›› Issue (4): 40203-040203.doi: 10.11889/j.1000-3436.2017.rrj.35.040203

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles     Next Articles

Radioprotective effects of a nitric oxide scavenger, Fe (DETC)2, on mice

LI Yuanyuan, ZHANG Yurui, XU Wenqing   

  1. Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
  • Received:2017-05-02 Revised:2017-05-18 Online:2017-08-20 Published:2017-07-29
  • Supported by:

    Supported by National Natural Science Foundation of China (81273005), Tianjin Municipal Science and Technology Commission (14JCZDJC36400)

Abstract:

A 30-day survival rate experiment was carried out, and the assays of peripheral blood leukocytes, bone marrow DNA content, colony forming units of the spleen (CFU-S), and organ index parameters were analyzed to evaluate the protective effect of a nitric oxide-specific scavenger, Fe2+-diethyldithiocarbamate complex (Fe(DETC)2), on radiation-injured mice. The results showed that compared with the irradiation group, the 30 d survival rate, peripheral blood leukocytes, bone marrow DNA content, CFU-S, and organ index were significantly different from those in the mice treated with different doses. In particular, DETC was administered intraperitoneally at a dose of 300 mg/kg, which increased the survival rate by about 43%, and changes in the number of white blood cells, bone marrow DNA content, and CFU-S were statistically significant (p<0.01). It is suggested that Fe(DETC)2, a nitric oxide scavenger, has a protective effect on radiation-injured mice.

Key words: Nitric oxide scavenger, Fe(DETC)2, Radiation protection

CLC Number: 

  • TL7