Journal of Radiation Research and Radiation Proces ›› 2017, Vol. 35 ›› Issue (3): 30102-030102.doi: 10.11889/j.1000-3436.2017.rrj.35.030102

• REVIEW • Previous Articles     Next Articles

Advances of exosome research in cancer radiotherapy and chemotherapy

LI Junjun, TU Wenzhi, LIU Yong   

  1. Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 201620, China
  • Received:2017-03-14 Revised:2017-04-29 Online:2017-06-20 Published:2017-06-15
  • Supported by:

    Supported by the “ational Nature Science Foundation of China” (31370838, 81602663), “Ministry of Education returned to study fund” (N130204) and “Shanghai Municipal Commission of Health and Family Planning” (20164Y0037)

Abstract:

Here, we summarized the isolation, enrichment, and tracking of exosome, as well as its application in radio-and chemotherapy of cancer. Currently, the main extracting methods of exosome include ultracentrifugation, ultrafiltration, and chromatography. Exosome can be tracked by luciferase labeling. Exosome is characterized by specific surface markers and exists in most body fluids, which makes it a potential cancer marker. Moreover, increasing researches have focused on the vital role of exosomes in radiosensitivity, radiation damage, targeted therapy, and multidrug resistance of cancer cells.

Key words: Exosomes, Radiotherapy, Chemotherapy, Cancer, Review

CLC Number: 

  • R73