Journal of Radiation Research and Radiation Proces ›› 2016, Vol. 34 ›› Issue (3): 30201-030201.doi: 10.11889/j.1000-3436.2016.rrj.34.030201

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles     Next Articles

Meta-analysis of dosimetric comparision between three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for breast cancer with conserving surgery

CUI Qinling, SUN Yan, ZHONG Wen, GUO Genyan, CHEN Yanzhi, ZHAO Yuxia   

  1. Department of Radiation Oncology of Cancer Center, Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
  • Received:2016-01-14 Revised:2016-03-06 Online:2016-06-20 Published:2016-04-29
  • Supported by:

    Supported by the Key Program of Clinical Diagnosis and Treatment of Hospital Reform in Liaoning Province (NCCC-B08-2014)


The aim was to evaluate the dosimetry superiority of IMRT (Intensity-modulated radiotherapy) in early-stage breast cancer with conserving surgery and provide more valuable evidences to the clinical researches. Clinical trials of dosimetric comparision between 3D-CRT and IMRT for early-stage breast cancer with conserving surgery were obtained from PubMed, EMbase, Sciencedirect, Wei pu, CNKI (China national knowledge Infrastructure), and Wanfang databases, which were evaluated and analyzed with the Cochrane Collaboration's RevMan 5.2.0 software. Fifteen samples were included. Compared with 3D-CRT plans, IMRT plans had a lower ipsilateral lung V20 (p=0.004), V30 (p=0.008), V40 (p=0.000 8), Dmax (p=0.001) and heart V30 (p=0.002), V40 (p<0.000 01), while had a higher ipsilateral lung V5 (p=0.000 5), V10 (p=0.05) and heart V5 (p<0.000 1), V10 (p=0.000 7). IMRT plans provided a significantly better coverage of the PTV V95 (p=0.05), V105 (p<0.000 1), V110 (p<0.000 01) and maximal dose (p<0.000 01). IMRT plans had a better dose homogeneity index and conformity index than 3D-CRT plans, both with p=0.02, but had a higher contralateral lung V5 (p=0.002), Dmax (p=0.000 4) and contralateral breast V3 (p=0.000 6). There was no significant difference between IMRT and 3D-CRT plans for V100, mean and minimal doses of PTV, ipsilateral lung mean dose, heart V20, maximum, mean dose, and contralateral mean dose, all p>0.05. Compared with 3D-CRT plans, IMRT plans had the dosimetry superiority for early-stage breast cancer with significantly better coverage and dose homogeneity of planning target volume while maintaining lower doses to high risk organs.

Key words: Breast cancer, Radiotherapy, Three-dimensional conformal radiotherapy (3D-CRT), Intensitymodulated radiotherapy (IMRT), Meta-analysis

CLC Number: 

  • R730.55