Journal of Radiation Research and Radiation Proces ›› 2016, Vol. 34 ›› Issue (1): 10501-010501.doi: 10.11889/j.1000-3436.2016.rrj.34.010501

• RADIATION DOSIMETRY • Previous Articles     Next Articles

Development of a new biodosimetry of serum iron

XIE Lihua  ZHANG Xiaohong  HU Xiaodan  CHEN Feng  ZHANG Zequn  LI Qun  ZHANG Haiqian   

  1. (Nanjing University of Aeronautics & Astronautics, Nanjing 210016, China)
  • Received:2015-09-27 Revised:2015-11-10 Online:2016-02-20 Published:2016-01-21
  • Contact: Ph.D. ZHANG Haiqian, professor E-mail:zhanghq@nuaa.edu.cn
  • About author:XIE Lihua, female, was born in February 1989 and graduated from University of South China in 2013. Now she is a master candidate of Nanjing University of Aeronautics and Astronautics, majoring in biological dosimeter
  • Supported by:

    Supported by National Defense Basic Scientific Research Project (B252013307), National Nature Science Foundation of China (11575086, 31400721), Nature Science Foundation of Jiangsu Province (BK20131355) and Priority Academic Program Development of Jiangsu Higher Education Institutions

Abstract:

The aim is to study the serum iron changes in vitro serum of human peripheral blood irradiated by Co-60 γ-rays and explore its feasibility as a biodosimetry. To establish the dose-response relationship, the concentration of serum iron in γ-rays irradiated serum was detected using ELISA(Enzymes linked immunosorbent assay). The results demonstrated that serum iron level increased with absorbed dose, and the dose-response curve of serum iron concentration followed the linear-quadratic model: male [y=30 676.5+2 383.5x-202.7x2 (r=0.99)], female [y=26 974.4+1 611.8x-141.3x2 (r=0.98)]. Time-response relationship of 4 Gy demonstrated that the serum iron was stable within 2 d. With the dose-response linear-quadratic curve, the absorbed dose was close to the double-blind dose (1, 2 and 4 Gy), and the 95% confidence interval of the estimated value was narrow. Therefore, the serum iron has the potential to be a new biodosimetry to reconstruct human exposure dose.

Key words: Biological dosimeter, Serum iron, γ-rays

CLC Number: 

  • Q691,TL72