Journal of Radiation Research and Radiation Proces ›› 2016, Vol. 34 ›› Issue (1): 10201-010201.doi: 10.11889/j.1000-3436.2016.rrj.34.010201

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles     Next Articles

Anti-tumor effects of mitochondria targeted antioxidant MitoQ

WANG Huawei  WANG Huanan  KANG Xiaomeng  ZHANG Yurui  YANG Fujun  XU Wenqing   

  1. (Perking Union Medicine College & Chinese Academy of Medical Sciences, Institute of Radiation Medicine,
    Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China)
  • Received:2015-09-11 Revised:2015-11-06 Online:2016-02-20 Published:2015-12-07
  • Contact: XU Wenqing, professor, master tutor E-mail:xuwenqing@irm-cams.ac.cn
  • About author:WANG Huawei, male, was born in September 1988 and graduated from Henan University in 2012. Now he is a master candidate in the Institute of Radiation Medicine Chinese Academy of Medical Sciences
  • Supported by:

    Supported by Tianjin Research Program of Application Foundation and Advanced Technology(14JCZDJC36400), Beijing Union Medical College Youth Fund(33320140124), and The Institute of Radiation Medicine Chinese Academy of Medical Sciences Research Fund(1555)

Abstract:

MTT was used to detect the cell toxicity of different concentrations of MitoQ on liver cancer HepG2 cells. Apoptosis-inducing assay was used to detect the apoptosis rate on liver cancer HepG2 cells after the treatment with varying MitoQ concentrations. Xenograft tumor model assay was used to investigate the anti-tumor effects of MitoQ on HepG2 hepatocarcinoma-bearing mice. The results showed that the inhibitory effects of MitoQ on HepG2 cells increased with MitoQ concentration, and compared with control group, administration group apoptosis rate was significantly higher(p<0.01). In nude mice xenograft tumor model assay, the tumor growth was all inhibited after the treatment with 1 mg/kg, 5 mg/kg, and 10 mg/kg MitoQ concentration after 10 d. When the mice were treated with 10 mg/kg MitoQ, tumor volume (p<0.01) and tumor mass (p<0.05) were significantly different from those of the blank group(p<0.01). The results indicate that MitoQ has antitumor effect in vivo and in vitro.

CLC Number: 

  • R96