1 尹勇, 于金明, 邢力刚.剂量体积直方图参数评估放射性肺损伤的作用[J].中华肿瘤杂志, 2003,25(04): 1-3.2 Vasic L, Durdevic P.[Radiation-induced lung damage--etiopathogenesis, clinical features, imaging findings and treatment][J].Med Pregl, 2012, 65(7-8): 319-325.3 Ghafoori P, Marks LB, Vujaskovic Z,et al.Radiation-induced lung injury. Assessment, management, and prevention[J].Oncology (Williston Park), 2008, 22(1): 37-47, 52-53.4 Zhao W, Robbins ME.Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications[J].Curr Med Chem, 2009, 16(2): 130-143.5 Trott KR, Herrmann T, Kasper M.Target cells in radiation pneumopathy[J].Int J Radiat Oncol Biol Phys, 2004, 58(2): 463-469.6 Sica A, Mantovani A.Macrophage plasticity and polarization: in vivo veritas[J].J Clin Invest, 2012, 122(3): 787-795.7 Varin A, Gordon S.Alternative activation of macrophages: immune function and cellular biology[J].Immunobiology, 2009, 214(7): 630-641.8 Gordon S, Martinez FO.Alternative activation of macrophages: mechanism and functions[J].Immunity, 2010, 32(5): 593-604.9 Zhang H, Han G, Liu H,et al.The development of classically and alternatively activated macrophages has different effects on the varied stages of radiation-induced pulmonary injury in mice[J].J Radiat Res, 2011, 52(6): 717-726.10 Yang K, Palm J, Konig J,et al.Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury[J].Int J Radiat Biol, 2007, 83(10): 665-676.11 Quan TE, Cowper SE, Bucala R.The role of circulating fibrocytes in fibrosis[J].Curr Rheumatol Rep, 2006, 8(2): 145-150.12 Epperly MW, Guo H, Gretton JE,et al.Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis[J].Am J Respir Cell Mol Biol, 2003, 29(2): 213-224.13 Zeisberg EM, Tarnavski O, Zeisberg M,et al.Endothelial-to-mesenchymal transition contributes to cardiac fibrosis[J].Nat Med, 2007, 13(8): 952-961.14 Willis BC, DuBois RM, Borok Z.Epithelial origin of myofibroblasts during fibrosis in the lung[J].Proc Am Thorac Soc, 2006, 3(4): 377-382.15 Zavadil J, Bottinger EP.TGF-beta and epithelial-to-mesenchymal transitions[J].Oncogene, 2005, 24(37): 5764-5774.16 Kim KK, Kugler MC, Wolters PJ,et al.Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix[J].Proc Natl Acad Sci U S A, 2006, 103(35): 13180-13185.17 Marmai C, Sutherland RE, Kim KK,et al.Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis[J].Am J Physiol Lung Cell Mol Physiol, 2011, 301(1): L71-L78.18 Tanjore H, Xu XC, Polosukhin VV,et al.Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis[J].Am J Respir Crit Care Med, 2009, 180(7): 657-665.19 Kalluri R, Neilson EG.Epithelial-mesenchymal transition and its implications for fibrosis[J].J Clin Invest, 2003, 112(12): 1776-1784.20 Derynck R, Zhang YE.Smad-dependent and Smad-independent pathways in TGF-beta family signalling[J].Nature, 2003, 425(6958): 577-584.21 Balli D, Ustiyan V, Zhang Y,et al.Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition[J].Embo J, 2013, 32(2): 231-244.22 Dennler S, Itoh S, Vivien D,et al.Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene[J].Embo J, 1998, 17(11): 3091-3100.23 Massague J, Seoane J, Wotton D.Smad transcription factors[J].Genes Dev, 2005, 19(23): 2783-2810.24 Masszi A, Di Ciano C, Sirokmany G,et al.Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition[J].Am J Physiol Renal Physiol, 2003, 284(5): F911-F924.25 Monceau V, Pasinetti N, Schupp C,et al.Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity[J].Curr Drug Targets, 2010, 11(11): 1395-1404.26 Zavadil J, Bottinger EP.TGF-beta and epithelial-to-mesenchymal transitions[J].Oncogene, 2005, 24(37): 5764-5774.27 Nagarajan D, Melo T, Deng Z,et al.ERK/GSK3beta/Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition[J].Free Radic Biol Med, 2012, 52(6): 983-992.28 Ghosh SN, Zhang R, Fish BL,et al.Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis[J].Int J Radiat Oncol Biol Phys, 2009, 75(5): 1528-1536.29 毛艳, 刘文其.放射性肺损伤防护的研究进展[J].肿瘤, 2012,32(5): 389-394.30 Travis EL, Parkins CS, Holmes SJ,et al.WR-2721 protection of pneumonitis and fibrosis in mouse lung after single doses of x rays[J].Int J Radiat Oncol Biol Phys, 1984, 10(2): 243-251.31 Pan J, Su Y, Hou X,et al.Protective effect of recombinant protein SOD-TAT on radiation-induced lung injury in mice[J].Life Sci, 2012, 91(3-4): 89-93.32 Gauter-Fleckenstein B, Fleckenstein K, Owzar K,et al.Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage[J].Free Radic Biol Med, 2010, 48(8): 1034-1043.33 Terasaki Y, Ohsawa I, Terasaki M,et al.Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress[J].Am J Physiol Lung Cell Mol Physiol, 2011, 301(4): L415-L426.34 Sekine I, Sumi M, Ito Y,et al.Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients[J].Radiother Oncol, 2006, 80(1): 93-97.35 Mathew B, Huang Y, Jacobson JR,et al.Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression[J].Am J Respir Cell Mol Biol, 2011, 44(3): 415-422.36 Puthawala K, Hadjiangelis N, Jacoby SC,et al.Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis[J].Am J Respir Crit Care Med, 2008, 177(1): 82-90.37 Hakenjos L, Bamberg M, Rodemann HP.TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype[J].Int J Radiat Biol, 2000, 76(4): 503-509.38 Anscher MS, Thrasher B, Zgonjanin L,et al.Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury[J].Int J Radiat Oncol Biol Phys, 2008, 71(3): 829-837.39 Flechsig P, Dadrich M, Bickelhaupt S,et al.LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-beta and BMP-associated proinflammatory and proangiogenic signals[J].Clin Cancer Res, 2012, 18(13): 3616-3627.40 Laping NJ, Grygielko E, Mathur A,et al.Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542[J].Mol Pharmacol, 2002, 62(1): 58-64.41 Li Y, Song LW, Peng RY,et al.[Effects of SB203580 and WP631 on Smad signal transduction pathway in lung fibroblasts after irradiation][J].Ai Zheng, 2008, 27(7): 698-702.42 Monceau V, Pasinetti N, Schupp C,et al.Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity[J].Curr Drug Targets, 2010, 11(11): 1395-1404.43 Bao P, Gao W, Li S,et al.Effect of pretreatment with high-dose ulinastatin in preventing radiation-induced pulmonary injury in rats[J].Eur J Pharmacol, 2009, 603(1-3): 114-119.44 Brickey WJ, Neuringer IP, Walton W,et al.MyD88 provides a protective role in long-term radiation-induced lung injury[J].Int J Radiat Biol, 2012, 88(4): 335-347.45 Stone ML, Sharma AK, Zhao Y,et al.Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury[J].Am J Physiol Lung Cell Mol Physiol, 2015, 308(12): L1245-L1252.46 Fujino N, Kubo H, Suzuki T,et al.Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice[J].Exp Lung Res, 2012, 38(1): 28-36.47 Wang C, Abe S, Matsuda K,et al.Effects of gefitinib on radiation-induced lung injury in mice[J].J Nippon Med Sch, 2008, 75(2): 96-105.48 Chen LX, Yang K, Sun M,et al.Fluorofenidone inhibits transforming growth factor-beta1-induced cardiac myofibroblast differentiation[J].Pharmazie, 2012, 67(5): 452-456.49 Przybyszewska M, Miloszewska J, Rzonca S,et al.Soluble TNF-alpha receptor I encoded on plasmid vector and its application in experimental gene therapy of radiation-induced lung fibrosis[J].Arch Immunol Ther Exp (Warsz), 2011, 59(4): 315-326.50 Bohm L.Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation[J].Radiat Oncol, 2006, 12(1): 1-8.51 Wand O, Kremer MR.[Novel therapies for idiopathic pulmonary fibrosis][J].Harefuah, 2015, 154(7): 446-450, 469, 468.52 Li Y, Song LW, Peng RY,et al.[Effects of SB203580 and WP631 on Smad signal transduction pathway in lung fibroblasts after irradiation][J].Ai Zheng, 2008, 27(7): 698-702.53 Molteni A, Moulder JE, Cohen EF,et al.Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker[J].Int J Radiat Biol, 2000, 76(4): 523-532. |