Journal of Radiation Research and Radiation Proces ›› 2015, Vol. 33 ›› Issue (6): 60201-060201.doi: 10.11889/j.1000-3436.2015.rrj.33.060201

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles     Next Articles

Effects of electromagnetic pulses on the heart and liver of rat and subsequent self-recovery

LIN Jinwen1  LIU He1  ZHANG Jie1  QI Hongxing1  SHEN Xiaoqin1  CHEN Shude1,2  WANG Xianghui1   

  1. 1(Institute of Biophysics, Department of Physics, East China Normal University, Shanghai 200241, China)
    2(State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China)
  • Received:2015-08-10 Revised:2015-11-01 Online:2015-12-20 Published:2015-12-07
  • Contact: Ph. D. WANG Xianghui, associate professor E-mail:xhwang@phy.ecnu.edu.cn
  • About author:LIN Jinwen, female, was born in December 1990, graduated from Hubei University of Arts and Science in 2012, major in biological physics, now is a master candidate,E-mail: jewel092@163.com
  • Supported by:

    Supported by National Basic Research Program of China (No. 2011CB503701)

Abstract:

The influences of W-EMP (Wide-band electromagnetic pulse) exposure (field strength: 110 kV/m or 140 kV/m, pulse number: 5 or 100, pulse leading edge width: 20 ns, and the pulse width: 200 ns) on the liver and heart tissue of male rat, as well as subsequent recovery behavior, were investigated. At 6 h, 1 d, 3 d, 7 d, and 10 d separately from after-exposure, samples were collected for following assays to characterize the early damage and self-recovery of tissues: serum biochemical indexes (ALT and AST) related to heart and liver were detected by automatic biochemical analyzer, and the content of apoptosis-related proteins (Bax and Bcl-2) in both liver and heart was measured by Enzyme linked immunosorbent assay (Elisa). The results showed that significantly decreased levels of serum biochemical indicators (ALT and AST) and elevated apoptosis-related proteins (Bax and Bcl-2) (p<0.05) in liver were detected at 6 h of after-exposure, and recovered to Sham level 1 d (ALT, AST, Bax) and 7 d (Bcl-2) later, which implied that the liver of rat was early damaged by W-EMP exposure and subsequently activated the self-recovery response. However, no significant changes were induced by the W-EMP in the heart tissues, so no self-recovery behavior was available for observation.

Key words: Wide-band electromagnetic pulse, Serum biochemical indexes, Apoptosis-related proteins, Recovery

CLC Number: 

  • Q691