Journal of Radiation Research and Radiation Proces ›› 2015, Vol. 33 ›› Issue (3): 30204-030204.doi: 10.11889/j.1000-3436.2015.rrj.33.030204

• RADIOBIOLOGY AND RADIOMEDICINE • Previous Articles     Next Articles

Serum AXL as biomarker for acute radiation exposure

LIU Qiong  HE Yin  SHEN Xianrong  JIANG Dingwen  HOU Dengyong  LIU Yuming   

  1. (Naval Medical Research Institute, Shanghai 200433, China)
  • Received:2015-02-06 Revised:2015-04-28 Online:2015-06-20 Published:2015-06-02

Abstract:

To assess the usability of serum AXL as a possible biomarker for acute radiation exposure, the baseline level and variations induced by radiation of serum AXL were analyzed. Three hundred male C57BL/6 mice were randomly divided into radiation groups (n=240) and the control (n=60). After 60Co total-body irradiation at the dose of 1, 3, 5 or 7 Gy respectively, mice were sacrificed and their serums were collected at 24, 48, or 72 h separately. Serum AXL concentration were then analyzed by antibody array. The results suggested that baseline level of serum AXL expression hold steady (186.3±44.20) pg/mL. Moreover, serum AXL concentration is inversely related to the radiation dose within 72 h after exposure. This study uncovers a strong correlation between serum AXL concentration and radiation dose, and serum AXL has a consequential ability to estimate radiation exposure as biomarker.

Key words: AXL, Cytokine, Bio-dosimetry, Ionizing radiation

CLC Number: 

  • R818.04,TL72