Journal of Radiation Research and Radiation Proces ›› 2015, Vol. 33 ›› Issue (1): 10101-010101.doi: 10.11889/j.1000-3436.2015.rrj.33.010101

• REVIEW •     Next Articles

Recent advances in mechanisms of radiation-induced fibrosis

LIU Qi1  SUN Yong1  XING Xing1,2  LIU Yong1,2   

  1. 1(Cancer Research Institute, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China)
    2(Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China)
  • Received:2014-07-21 Revised:2014-11-03 Online:2015-02-20 Published:2015-01-07
  • Contact: LIU YONG E-mail:drliuyong@hotmail.com

Abstract:

Radiation therapy is an effective treatment for solid tumors. Its effectiveness results from DNA damage of tumor cells induced by ionizing radiation (IR). However, IR can also destroy normal tissues surrounding tumors in treatment of cancer. Early damages are featured with acute inflammatory response. Late damages are characterized by fibrosis, which would affect the structure and function of the targeting organs, even threaten the quality of patients’ life. Previous studies suggested that radiation fibrosis process involves multiple cytokines, multiplex reactions and changes in the microenvironment. Here we review the current progress of molecular mechanisms on radiation-induced fibrosis.

Key words: Radiation, Normal tissue, Late damage, Fibrosis

CLC Number: 

  • R730.55,TL71