Journal of Radiation Research and Radiation Proces ›› 2014, Vol. 32 ›› Issue (5): 3-050202.doi: 10.11889/j.1000-3436.2014.rrj.32.050202

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Study on ultra-small gold nanoclusters as X-rays computed tomography contrast agent

SONG Shasha1  WANG Junying1  CHEN Jie1  SHEN Xiu1  WANG Hao1  GAO Kai2  ZHANG Xiaodong1  SUN Yuanming1   

  1. 1(Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College,
    Tianjin 300192, China)
    2(Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College,
    Beijing 100021,China)
  • Received:2014-06-17 Revised:2014-08-26 Online:2014-10-20 Published:2014-09-15

Abstract:

To assess the feasibility of ultra-small GSH-protected Au nanoclusters (NCs) employed as X-ray computed  tomography (CT) contrast agent and study the effects of efficient uptake and clearance, CT values and time-dependent two- and three-dimensional images were recorded. The CT values of tumor region showed that the enhanced comparison gradually increased with the time. And the high enhanced comparison can also be reflected by distinct images until 6 h later. Therefore, high uptake of cancerous cell was proved by the CT values and two/three-images, which contributes to the application of Au NCs in tumor target imaging. High CT values of bladder were detected from the beginning, showing that Au NCs can permeate kidney tissue and be cleared by bladder. And the enhancement comparison of kidney revealed the possible application of exploration damage and lesion as probe.

CLC Number: 

  • R811