Journal of Radiation Research and Radiation Proces ›› 2014, Vol. 32 ›› Issue (5): 1-050101.doi: 10.11889/j.1000-3436.2014.rrj.32.050101

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Review on the mechanism of surface ehanced Raman spectroscope (SERS) and its biomedical application

WANG Dongfang1,2  SONG Shiping1   

  1. 1(Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Jiading Campus, 
    Shanghai 201800, China)
    (University of Chinese Academy of Sciences, Beijing 100049, China)
  • Received:2014-04-18 Revised:2014-05-14 Online:2014-10-20 Published:2014-06-06


The fundamental mechanism of SERS (Surface ehanced Raman spectroscope), such as electromagnetic and chemical effect, as well as the synthesis of SERS tags with high enhancement, which will be applied in single molecule detection and single cell imaging, were discussed. For applications, SERS nanoparticle tags have been developed based on the use of embedded reporter molecules and a silica or polymer encapsulation layer. The SERS nanoparticle tags are capable of providing detailed spectroscopic information. These properties have raised new opportunities for multiplexed molecular diagnosis and in vivo Raman spectroscopy and imaging.

Key words: Review, Surface ehanced Raman spectroscope(SERS), Biomedical application, SERS imaging, Surface plasmon resonance

CLC Number: 

  • O657.37,TL65