The determination of absorbed doses for sterilization of shu-ganwan and evaluation for effects of irradiated shu-ganwan on liver function of rat

YAO Qingwan1,2  LIU Qingfang1

1. 1 (School of Public Health, Soochow University, Suzhou 215123, China)
2 (Center for Disease Control and Prevention of Kunshan, Kunshan 215301, China)
• Received:2011-11-17 Revised:2011-12-30 Online:2012-08-20 Published:2014-09-11

Abstract:

The absorbed dose of irradiation sterilization for Shu-Gan Wan and the effects of irradiated Shu-Gan Wan on rat liver function was investigated to provide the scientific basis for its clinical safety applications. The amount range of contaminating bacteria in original Shu-Gan Wan was determined before irradiation and the D10 & SD were calculated after irradiation. The irradiated Shu-Gan Wan were given to the rats and the biochemical items of liver were measured before and after-irradiation. The experimental results show that the amount range of contaminating bacteria count of the Shu-Gan Wan is 50-1800 CFU/g, the D10 value is 1.81 kGy and the minimum bactericidal dose has been calculated to be 11.322 kGy. The 60Co radiation dose for sterilization of Shu-Gan Wan has been suggested to be 11.322 kGy and irradiated Shu-Gan Wan has no significant damage to liver function of the rat.

CLC Number:

• R817，R144.1