Journal of Radiation Research and Radiation Proces ›› 2012, Vol. 30 ›› Issue (4): 215-220.doi: 10.11889/j.1000-3436.2012.rrj.30.120405

Previous Articles     Next Articles

The determination of absorbed doses for sterilization of shu-ganwan and evaluation for effects of irradiated shu-ganwan on liver function of rat

YAO Qingwan1,2  LIU Qingfang1   

  1. 1 (School of Public Health, Soochow University, Suzhou 215123, China)
    2 (Center for Disease Control and Prevention of Kunshan, Kunshan 215301, China)
  • Received:2011-11-17 Revised:2011-12-30 Online:2012-08-20 Published:2014-09-11

Abstract:

The absorbed dose of irradiation sterilization for Shu-Gan Wan and the effects of irradiated Shu-Gan Wan on rat liver function was investigated to provide the scientific basis for its clinical safety applications. The amount range of contaminating bacteria in original Shu-Gan Wan was determined before irradiation and the D10 & SD were calculated after irradiation. The irradiated Shu-Gan Wan were given to the rats and the biochemical items of liver were measured before and after-irradiation. The experimental results show that the amount range of contaminating bacteria count of the Shu-Gan Wan is 50-1800 CFU/g, the D10 value is 1.81 kGy and the minimum bactericidal dose has been calculated to be 11.322 kGy. The 60Co radiation dose for sterilization of Shu-Gan Wan has been suggested to be 11.322 kGy and irradiated Shu-Gan Wan has no significant damage to liver function of the rat.

Key words: Shu-Gan Wan, Radiation sterilization, D10value, Bactericidal does, Impact on liver function

CLC Number: 

  • R817,R144.1